Projects per year
Results: DNAm GrimAge predicted incidence of clinically diagnosed chronic obstructive pulmonary disease (COPD), type 2 diabetes and ischemic heart disease after thirteen years of follow-up (Hazard Ratios = 2.22, 1.52 and 1.41, respectively). DunedinPoAm predicted incidence of COPD and lung cancer (Hazard Ratios = 2.02 and 1.45, respectively). DNAm PhenoAge predicted incidence of type 2 diabetes (Hazard Ratio = 1.54). DNAm Telomere Length associated with incidence of ischemic heart disease (Hazard Ratio = 0.80). DNAm GrimAge associated with all-cause mortality, prevalence of COPD and spirometry measures at study baseline. These associations were present after adjusting for possibly confounding risk factors including alcohol consumption, body mass index, deprivation, education and tobacco smoking, and surpassed stringent Bonferroni-corrected significance thresholds.
Conclusions: Our data suggest that epigenetic measures of ageing may have utility in clinical settings to complement gold-standard methods for disease assessment and management.
- DNA methylation
- biological ageing
- epigenetic age acceleration