Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy

Terri S Armstrong; Robin Grant; Mark R Gilbert; Jong Woo Lee; Andrew D Norden

doi:10.1093/neuonc/nov269

Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy

Terri S Armstrong, Robin Grant, Mark R Gilbert, Jong Woo Lee, Andrew D Norden

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.

Original language	English
Journal	Neuro-Oncology
DOIs	https://doi.org/10.1093/neuonc/nov269
Publication status	Published - 2 Nov 2015

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@article{fd6a5b86f7ed4e9e92bc14132c81b66d,

title = "Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy",

abstract = "Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.",

author = "Armstrong, {Terri S} and Robin Grant and Gilbert, {Mark R} and Lee, {Jong Woo} and Norden, {Andrew D}",

note = "{\textcopyright} The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

year = "2015",

month = nov,

day = "2",

doi = "10.1093/neuonc/nov269",

language = "English",

journal = "Neuro-Oncology",

issn = "1522-8517",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - Epilepsy in glioma patients

T2 - mechanisms, management, and impact of anticonvulsant therapy

AU - Armstrong, Terri S

AU - Grant, Robin

AU - Gilbert, Mark R

AU - Lee, Jong Woo

AU - Norden, Andrew D

PY - 2015/11/2

Y1 - 2015/11/2

N2 - Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.

AB - Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.

U2 - 10.1093/neuonc/nov269

DO - 10.1093/neuonc/nov269

M3 - Literature review

C2 - 26527735

SN - 1522-8517

JO - Neuro-Oncology

JF - Neuro-Oncology

ER -

Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy

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