(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Amela Jusic; Konstantinos  Stellos; Lino  Ferreira; Andrew H Baker; Yvan Devaux

doi:10.1016/j.jmccpl.2022.100013

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Amela Jusic, Konstantinos Stellos, Lino Ferreira, Andrew H Baker, Yvan Devaux^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality.
The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19.
In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

Original language	English
Journal	Journal of Molecular and Cellular Cardiology Plus
Early online date	28 Jul 2022
DOIs	https://doi.org/10.1016/j.jmccpl.2022.100013
Publication status	E-pub ahead of print - 28 Jul 2022

Keywords / Materials (for Non-textual outputs)

brain-heart axis
COVID-19
RNAs

Access to Document

10.1016/j.jmccpl.2022.100013

JMCC_v002-revised_cleanAccepted author manuscript, 1.18 MBLicence: Creative Commons: Attribution (CC-BY)
1-s2.0-S2772976122000071-mainProof, 1.73 MBLicence: Creative Commons: Attribution (CC-BY)

2 Active
3 Finished

Exploitation of the Response to Injury in Saphenous Vein Bypass Grafts
Baker, A., Hadoke, P., Henderson, N., Newby, D. & Rodor, J.
UK-based charities
1/04/20 → 31/03/25
Project: Research
BHF Chair Transfer from Glasgow
Baker, A.
UK-based charities
1/10/15 → 31/07/26
Project: Research
COVIRNA: A diagnostic test to improve surveillance and care of COVID-19 patients
Baker, A.
EU government bodies
1/11/20 → 31/10/22
Project: Research

Cite this

@article{2244535acbff41f6a16ce3dc7d08bcb0,

title = "(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19",

abstract = "Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease. ",

keywords = "brain-heart axis, COVID-19, RNAs",

author = "Amela Jusic and Konstantinos Stellos and Lino Ferreira and Baker, {Andrew H} and Yvan Devaux",

year = "2022",

month = jul,

day = "28",

doi = "10.1016/j.jmccpl.2022.100013",

language = "English",

journal = "Journal of Molecular and Cellular Cardiology Plus",

issn = "2772-9761",

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TY - JOUR

T1 - (Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

AU - Jusic, Amela

AU - Stellos, Konstantinos

AU - Ferreira, Lino

AU - Baker, Andrew H

AU - Devaux, Yvan

PY - 2022/7/28

Y1 - 2022/7/28

N2 - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

AB - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.

KW - brain-heart axis

KW - COVID-19

KW - RNAs

U2 - 10.1016/j.jmccpl.2022.100013

DO - 10.1016/j.jmccpl.2022.100013

M3 - Review article

SN - 2772-9761

JO - Journal of Molecular and Cellular Cardiology Plus

JF - Journal of Molecular and Cellular Cardiology Plus

ER -

(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Exploitation of the Response to Injury in Saphenous Vein Bypass Grafts

BHF Chair Transfer from Glasgow

COVIRNA: A diagnostic test to improve surveillance and care of COVID-19 patients

Cite this