(Epi)transcriptomics in cardiovascular and neurological complications of COVID-19

Amela Jusic, Konstantinos Stellos, Lino Ferreira, Andrew H Baker, Yvan Devaux*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality.
The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS‐CoV‐2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19.
In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.
Original languageEnglish
JournalJournal of Molecular and Cellular Cardiology Plus
Early online date28 Jul 2022
DOIs
Publication statusE-pub ahead of print - 28 Jul 2022

Keywords

  • brain-heart axis
  • COVID-19
  • RNAs

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