erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish

David A Lyons; Hans-Martin Pogoda; Matthew G Voas; Ian G Woods; Brianne Diamond; Rebecca Nix; Naomi Arana; Jennifer Jacobs; William S Talbot

doi:10.1016/j.cub.2005.02.030

erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish

David A Lyons, Hans-Martin Pogoda, Matthew G Voas, Ian G Woods, Brianne Diamond, Rebecca Nix, Naomi Arana, Jennifer Jacobs, William S Talbot

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Myelin is critical for efficient axonal conduction in the vertebrate nervous system. Neuregulin (Nrg) ligands and their ErbB receptors are required for the development of Schwann cells, the glial cells that form myelin in the peripheral nervous system. Previous studies have not determined whether Nrg-ErbB signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migration, or the onset of myelination.

Original language	English
Pages (from-to)	513-24
Number of pages	12
Journal	Current biology : CB
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.cub.2005.02.030
Publication status	Published - 2005

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10.1016/j.cub.2005.02.030

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title = "erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish",

abstract = "Myelin is critical for efficient axonal conduction in the vertebrate nervous system. Neuregulin (Nrg) ligands and their ErbB receptors are required for the development of Schwann cells, the glial cells that form myelin in the peripheral nervous system. Previous studies have not determined whether Nrg-ErbB signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migration, or the onset of myelination.",

author = "Lyons, {David A} and Hans-Martin Pogoda and Voas, {Matthew G} and Woods, {Ian G} and Brianne Diamond and Rebecca Nix and Naomi Arana and Jennifer Jacobs and Talbot, {William S}",

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T1 - erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish

AU - Lyons, David A

AU - Pogoda, Hans-Martin

AU - Voas, Matthew G

AU - Woods, Ian G

AU - Diamond, Brianne

AU - Nix, Rebecca

AU - Arana, Naomi

AU - Jacobs, Jennifer

AU - Talbot, William S

PY - 2005

Y1 - 2005

N2 - Myelin is critical for efficient axonal conduction in the vertebrate nervous system. Neuregulin (Nrg) ligands and their ErbB receptors are required for the development of Schwann cells, the glial cells that form myelin in the peripheral nervous system. Previous studies have not determined whether Nrg-ErbB signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migration, or the onset of myelination.

AB - Myelin is critical for efficient axonal conduction in the vertebrate nervous system. Neuregulin (Nrg) ligands and their ErbB receptors are required for the development of Schwann cells, the glial cells that form myelin in the peripheral nervous system. Previous studies have not determined whether Nrg-ErbB signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migration, or the onset of myelination.

U2 - 10.1016/j.cub.2005.02.030

DO - 10.1016/j.cub.2005.02.030

M3 - Article

C2 - 15797019

VL - 15

SP - 513

EP - 524

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 6

ER -

erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish

Abstract

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