Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Bill Earnshaw, Robin Allshire, B.E. Black, K. Bloom, Edward D Salmon, B.R. Brinkley, W. Brown, I.M. Cheesman, K.H.A. Choo, G.P. Copenhaver, J.G. DeLuca, et al (47 other authors)

Research output: Contribution to journalArticlepeer-review

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
Original languageEnglish
Pages (from-to)101-106
JournalChromosome Research
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • centromere
  • CENP-A
  • histone
  • kinetochore
  • CenH3

Fingerprint

Dive into the research topics of 'Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant'. Together they form a unique fingerprint.

Cite this