Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Bill Earnshaw; Robin Allshire; B.E. Black; K. Bloom; Edward D Salmon; B.R. Brinkley; W. Brown; I.M. Cheesman; K.H.A. Choo; G.P. Copenhaver; J.G. DeLuca; et al (47 other authors)

doi:10.1007/s10577-013-9347-y

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Bill Earnshaw, Robin Allshire, B.E. Black, K. Bloom, Edward D Salmon, B.R. Brinkley, W. Brown, I.M. Cheesman, K.H.A. Choo, G.P. Copenhaver, J.G. DeLuca, et al (47 other authors)

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Original language	English
Pages (from-to)	101-106
Journal	Chromosome Research
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s10577-013-9347-y
Publication status	Published - Apr 2013

Keywords / Materials (for Non-textual outputs)

centromere
CENP-A
histone
kinetochore
CenH3

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title = "Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant",

abstract = "The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.",

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AU - Earnshaw, Bill

AU - Allshire, Robin

AU - Black, B.E.

AU - Bloom, K.

AU - Salmon, Edward D

AU - Brinkley, B.R.

AU - Brown, W.

AU - Cheesman, I.M.

AU - Choo, K.H.A.

AU - Copenhaver, G.P.

AU - DeLuca, J.G.

AU - (47 other authors), et al

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AB - The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

KW - centromere

KW - CENP-A

KW - histone

KW - kinetochore

KW - CenH3

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IS - 2

ER -

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Abstract

Keywords / Materials (for Non-textual outputs)

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