Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

Yves Benninger, Tina Thurnherr, Jorge A Pereira, Sven Krause, Xunwei Wu, Anna Chrostek-Grashoff, Dominik Herzog, Klaus-Armin Nave, Robin J M Franklin, Dies Meijer, Cord Brakebusch, Ueli Suter, João B Relvas

Research output: Contribution to journalArticlepeer-review

Abstract

During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.
Original languageEnglish
Pages (from-to)1051-61
Number of pages11
JournalJournal of Cell Biology
Volume177
Issue number6
DOIs
Publication statusPublished - 18 Jun 2007

Keywords

  • Animals
  • Axons
  • Cell Surface Extensions
  • Mice
  • Mice, Knockout
  • Neuropeptides
  • Peripheral Nervous System
  • Schwann Cells
  • cdc42 GTP-Binding Protein
  • rac GTP-Binding Proteins
  • rac1 GTP-Binding Protein

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