Estimating constrained multi-fiber diffusion MR volumes by orientation clustering

Ryan P Cabeen, Mark E Bastin, David H Laidlaw

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Diffusion MRI is a valuable tool for mapping tissue microstructure; however, multi-fiber models present challenges to image analysis operations. In this paper, we present a method for estimating models for such operations by clustering fiber orientations. Our approach is applied to ball-and-stick diffusion models, which include an isotropic tensor and multiple sticks encoding fiber volume and orientation. We consider operations which can be generalized to a weighted combination of fibers and present a method for representing such combinations with a mixture-of-Watsons model, learning its parameters by Expectation Maximization. We evaluate this approach with two experiments. First, we show it is effective for filtering in the presence of synthetic noise. Second, we demonstrate interpolation and averaging by construction of a tractography atlas, showing improved reconstruction of white matter pathways. These experiments indicate that our method is useful in estimating multi-fiber ball-and-stick diffusion volumes resulting from a range of image analysis operations.
Original languageEnglish
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Number of pages8
Publication statusPublished - 2013


  • Algorithms
  • Brain
  • Computer Simulation
  • Diffusion Tensor Imaging
  • Humans
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Imaging, Three-Dimensional
  • Information Storage and Retrieval
  • Models, Neurological
  • Models, Statistical
  • Nerve Fibers, Myelinated
  • Pattern Recognition, Automated
  • Reproducibility of Results
  • Sensitivity and Specificity

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