Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

Lisa S. Nolan; Hannes Maier; Irm Hermans-Borgmeyer; Giorgia Girotto; Russell Ecob; Nicola Pirastu; Barbara A. Cadge; Christian Huebner; Paolo Gasparini; David P. Strachan; Adrian Davis; Sally J. Dawson

doi:10.1016/j.neurobiolaging.2013.02.009

Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

Lisa S. Nolan, Hannes Maier, Irm Hermans-Borgmeyer, Giorgia Girotto, Russell Ecob, Nicola Pirastu, Barbara A. Cadge, Christian Huebner, Paolo Gasparini, David P. Strachan, Adrian Davis, Sally J. Dawson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice. (c) 2013 Elsevier Inc. All rights reserved.

Original language	English
Article number	ARTN 2077.e1
Number of pages	9
Journal	Neurobiology of Aging
Volume	34
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.02.009
Publication status	Published - 26 Mar 2013

Keywords / Materials (for Non-textual outputs)

Age-related hearing loss
Estrogen
Gene
ESRRG
GENOME-WIDE ASSOCIATION
SEX-DIFFERENCES
OLDER-ADULTS
AGE
IMPAIRMENT
GENE
HEALTH
LOCI
POLYMORPHISM
PRESBYCUSIS

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10.1016/j.neurobiolaging.2013.02.009

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Nolan, L. S., Maier, H., Hermans-Borgmeyer, I., Girotto, G., Ecob, R., Pirastu, N., Cadge, B. A., Huebner, C., Gasparini, P., Strachan, D. P., Davis, A., & Dawson, S. J. (2013). Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. Neurobiology of Aging, 34(8), Article ARTN 2077.e1. https://doi.org/10.1016/j.neurobiolaging.2013.02.009

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title = "Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice",

abstract = "Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice. (c) 2013 Elsevier Inc. All rights reserved.",

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author = "Nolan, {Lisa S.} and Hannes Maier and Irm Hermans-Borgmeyer and Giorgia Girotto and Russell Ecob and Nicola Pirastu and Cadge, {Barbara A.} and Christian Huebner and Paolo Gasparini and Strachan, {David P.} and Adrian Davis and Dawson, {Sally J.}",

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T2 - evidence of a role in humans and mice

AU - Nolan, Lisa S.

AU - Maier, Hannes

AU - Hermans-Borgmeyer, Irm

AU - Girotto, Giorgia

AU - Ecob, Russell

AU - Pirastu, Nicola

AU - Cadge, Barbara A.

AU - Huebner, Christian

AU - Gasparini, Paolo

AU - Strachan, David P.

AU - Davis, Adrian

AU - Dawson, Sally J.

PY - 2013/3/26

Y1 - 2013/3/26

N2 - Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice. (c) 2013 Elsevier Inc. All rights reserved.

AB - Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice. (c) 2013 Elsevier Inc. All rights reserved.

KW - Age-related hearing loss

KW - Estrogen

KW - Gene

KW - ESRRG

KW - GENOME-WIDE ASSOCIATION

KW - SEX-DIFFERENCES

KW - OLDER-ADULTS

KW - AGE

KW - IMPAIRMENT

KW - GENE

KW - HEALTH

KW - LOCI

KW - POLYMORPHISM

KW - PRESBYCUSIS

U2 - 10.1016/j.neurobiolaging.2013.02.009

DO - 10.1016/j.neurobiolaging.2013.02.009

M3 - Article

SN - 0197-4580

VL - 34

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 8

M1 - ARTN 2077.e1

ER -

Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

Abstract

Keywords / Materials (for Non-textual outputs)

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