Ethical issues in non-intervention trials for thyroid cancer

P. Angelos*, D. M. Hartl, J. P. Shah, I. J. Nixon, R. P. Owen, A. Rinaldo, J. P. Rodrigo, A. R. Shaha, C. E. Silver, C. Suárez, A. Ferlito

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalEuropean Journal of Surgical Oncology (EJSO)
Issue number3
Publication statusPublished - 1 Mar 2018


  • Clinical trials
  • Equipoise
  • Ethics
  • Non-intervention
  • Research ethics
  • Thyroid cancer


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