Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain

Teresa E Levers, Steven Tait, Marie-Christine Birling, Peter J Brophy, David J Price

Research output: Contribution to journalArticlepeer-review

Abstract

The gene encoding human neuroblastoma apoptosis-related RNA binding protein (NAPOR) has rat and mouse homologues, Etr-r3 and mNapor, cloned recently by ourselves and others. Etr-r3/mNapor is transcribed in embryonic brain but its detailed expression patterns are unknown. It has been hypothesised that its expression coincides with the occurrence of programmed cell death, but existing expression data are insufficient to evaluate this possibility. We used northern blots and in situ hybridisation to show that Etr-r3/mNapor is expressed by most postmitotic differentiating cells throughout the forebrain during embryogenesis and the first weeks of postnatal life. Expression is particularly high in the developing cerebral cortex, in nuclei of the ventral telencephalon, in dorsal thalamus and in hypothalamus. In contrast, Etr-r3/mNapor is expressed by very few cells in proliferative regions, where cell death rates are highest.
Original languageEnglish
Pages (from-to)191-3
Number of pages3
JournalMechanisms of Development
Volume112
Issue number1-2
Publication statusPublished - 2002

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