Eukaryotic domain evolution inferred from genome comparisons

Richard R Copley, Leo Goodstadt, Chris Ponting

Research output: Contribution to journalArticlepeer-review


Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms.

Original languageEnglish
Pages (from-to)623-8
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number6
Publication statusPublished - Dec 2003


  • Animals
  • Eukaryotic Cells
  • Evolution, Molecular
  • Gene Duplication
  • Genome
  • Humans
  • Protein Structure, Tertiary
  • Selection, Genetic


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