European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt; Colin D. Veal; Lea Ter Meulen; Charalambos Chrysostomou; Wiesje Van Der Flier; Giovanni B. Frisoni; Idris Guessous; Miia Kivipelto; Moira Marizzoni; Pablo Martinez-lage; José Luis Molinuevo; David Porteous; Karen Ritchie; Philip Scheltens; Pierre-jean Ousset; Craig W. Ritchie; Gerald Luscan; Anthony J. Brookes; Pieter Jelle Visser

doi:10.1016/j.jalz.2018.02.010

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt, Colin D. Veal, Lea Ter Meulen, Charalambos Chrysostomou, Wiesje Van Der Flier, Giovanni B. Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-lage, José Luis Molinuevo, David Porteous, Karen Ritchie, Philip Scheltens, Pierre-jean Ousset, Craig W. Ritchie, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction
It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.

Methods
A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.

Results
To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.

Discussion
This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

Original language	English
Pages (from-to)	837-842
Number of pages	6
Journal	Alzheimer's & Dementia
Volume	14
Issue number	6
Early online date	28 Mar 2018
DOIs	https://doi.org/10.1016/j.jalz.2018.02.010
Publication status	Published - 1 Jun 2018

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10.1016/j.jalz.2018.02.010

2017-12-05 EPAD Registry Manuscript AcceptedAccepted author manuscript, 84.4 KBLicence: CC BY-NC-ND

https://linkinghub.elsevier.com/retrieve/pii/S1552526018300645

3 Finished

Stratifying Resilience and Depression Longitudinally
McIntosh, A., Deary, I., Evans, K., Haley, C. & Porteous, D.
UK-based charities
1/01/15 → 30/06/21
Project: Research
Generation Scotland
Porteous, D.
UK central government bodies/local authorities, health and hospital authorities
1/04/11 → 31/03/14
Project: Research
Genetic Health 21st Century
Porteous, D., Laurie, G. & Tait, J.
UK central government bodies/local authorities, health and hospital authorities
1/10/03 → 31/08/07
Project: Research

Cite this

Vermunt, L., Veal, C. D., Ter Meulen, L., Chrysostomou, C., Van Der Flier, W., Frisoni, G. B., Guessous, I., Kivipelto, M., Marizzoni, M., Martinez-lage, P., Molinuevo, J. L., Porteous, D., Ritchie, K., Scheltens, P., Ousset, P., Ritchie, C. W., Luscan, G., Brookes, A. J., & Visser, P. J. (2018). European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials. Alzheimer's & Dementia, 14(6), 837-842. https://doi.org/10.1016/j.jalz.2018.02.010

@article{9242ad5c333a499a864b54210c547250,

title = "European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials",

abstract = "IntroductionIt is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.MethodsA virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.ResultsTo date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.DiscussionThis study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.",

author = "Lisa Vermunt and Veal, {Colin D.} and {Ter Meulen}, Lea and Charalambos Chrysostomou and {Van Der Flier}, Wiesje and Frisoni, {Giovanni B.} and Idris Guessous and Miia Kivipelto and Moira Marizzoni and Pablo Martinez-lage and Molinuevo, {Jos{\'e} Luis} and David Porteous and Karen Ritchie and Philip Scheltens and Pierre-jean Ousset and Ritchie, {Craig W.} and Gerald Luscan and Brookes, {Anthony J.} and Visser, {Pieter Jelle}",

year = "2018",

month = jun,

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doi = "10.1016/j.jalz.2018.02.010",

language = "English",

volume = "14",

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journal = "Alzheimer's & Dementia",

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publisher = "Elsevier Inc.",

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Vermunt, L, Veal, CD, Ter Meulen, L, Chrysostomou, C, Van Der Flier, W, Frisoni, GB, Guessous, I, Kivipelto, M, Marizzoni, M, Martinez-lage, P, Molinuevo, JL, Porteous, D, Ritchie, K, Scheltens, P, Ousset, P, Ritchie, CW, Luscan, G, Brookes, AJ & Visser, PJ 2018, 'European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials', Alzheimer's & Dementia, vol. 14, no. 6, pp. 837-842. https://doi.org/10.1016/j.jalz.2018.02.010

TY - JOUR

T1 - European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

AU - Vermunt, Lisa

AU - Veal, Colin D.

AU - Ter Meulen, Lea

AU - Chrysostomou, Charalambos

AU - Van Der Flier, Wiesje

AU - Frisoni, Giovanni B.

AU - Guessous, Idris

AU - Kivipelto, Miia

AU - Marizzoni, Moira

AU - Martinez-lage, Pablo

AU - Molinuevo, José Luis

AU - Porteous, David

AU - Ritchie, Karen

AU - Scheltens, Philip

AU - Ousset, Pierre-jean

AU - Ritchie, Craig W.

AU - Luscan, Gerald

AU - Brookes, Anthony J.

AU - Visser, Pieter Jelle

PY - 2018/6/1

Y1 - 2018/6/1

N2 - IntroductionIt is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.MethodsA virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.ResultsTo date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.DiscussionThis study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

AB - IntroductionIt is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.MethodsA virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.ResultsTo date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.DiscussionThis study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

U2 - 10.1016/j.jalz.2018.02.010

DO - 10.1016/j.jalz.2018.02.010

M3 - Article

VL - 14

SP - 837

EP - 842

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 6

ER -

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Abstract

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Projects

Stratifying Resilience and Depression Longitudinally

Generation Scotland

Genetic Health 21st Century

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