EVA regulates thymic stromal organisation and early thymocyte development

Lucia DeMonte, Simona Porcellini, Elisiana Tafi, Julie Sheridan, Julie Gordon, Marianne Depreter, Natalie Blair, Maddalena Panigada, Francesca Sanvito, Barbara Merati, Anita Albientz, Thomas Barthlott, Laurence Ozmen, C. Clare Blackburn, Maria Guttinger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial V-like antigen (EVA) is an immunoglobulin-like adhesion molecule identified in a screen for molecules developmentally regulated at the DN to DP progression in thymocyte development. We show that EVA is expressed during the early stages of thymus organogenesis in both fetal thymic epithelia and T cell precursors, and is progressively downregulated from day 16.5 of embryonic development. In the postnatal thymus, EVA expression is restricted to epithelial cells and is distributed throughout both cortical and medullary thymic regions. Transgenic overexpression of EVA in the thymus cortex resulted in a modified stromal environment, which elicited an increase in organ size and absolute cell number. Although peripheral T lymphocyte numbers are augmented throughout life, no imbalance either in the repertoire, or in the different T cell subsets was detected. Collectively, these data suggest a role for EVA in structural organisation of the thymus and early lymphocyte development.

Original languageEnglish
Pages (from-to)334-340
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume356
Issue number2
DOIs
Publication statusPublished - 4 May 2007

Keywords

  • Adhesion molecules
  • T cell development
  • Thymic epithelium
  • Thymus

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