Evaluating (99m)Tc Auger electrons for targeted tumor radiotherapy by computational methods

Adriana Alexandre S. Tavares*, Joao Manuel R. S. Tavares

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Technetium-99m ((99m)Tc) has been widely used as an imaging agent but only recently has been considered for therapeutic applications. This study aims to analyze the potential use of (99m)Tc Auger electrons for targeted tumor radiotherapy by evaluating the DNA damage and its probability of correct repair and by studying the cellular kinetics, following (99m)Tc Auger electron irradiation in comparison to iodine-131 ((131)I) beta minus particles and astatine-211 ((211)At) alpha particle irradiation.

Methods: Computational models were used to estimate the yield of DNA damage (fast Monte Carlo damage algorithm), the probability of correct repair (Monte Carlo excision repair algorithm), and cell kinetic effects (virtual cell radiobiology algorithm) after irradiation with the selected particles.

Results: The results obtained with the algorithms used suggested that (99m)Tc CKMMX (all M-shell Coster-Kroning-CK- and super-CK transitions) electrons and Auger MXY (all M-shell Auger transitions) have a therapeutic potential comparable to high linear energy transfer (211)At alpha particles and higher than (131)I beta minus particles. All the other (99m)Tc electrons had a therapeutic potential similar to (131)I beta minus particles.

Conclusions: (99m)Tc CKMMX electrons and Auger MXY presented a higher probability to induce apoptosis than (131)I beta minus particles and a probability similar to (211)At alpha particles. Based on the results here, (99m)Tc CKMMX electrons and Auger MXY are useful electrons for targeted tumor radiotherapy. (c) 2010 American Association of Physicists in Medicine. [DOI: 10.1118/1.3451117]

Original languageEnglish
Pages (from-to)3551-3559
Number of pages9
JournalMedical physics
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • targeted tumor radiotherapy
  • computational methods
  • NUCLEOTIDE EXCISION-REPAIR
  • MONTE-CARLO-SIMULATION
  • INDUCED DNA-DAMAGE
  • GROUP NO 6
  • LOW-ENERGY
  • RADIATION
  • THERAPY
  • RADIONUCLIDES
  • EMISSION
  • EMITTERS

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