Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

Brian R.  Lindman; Devraj  Sukul; Marc R Dweck; Mahesh V.  Madhavan; Benoit J Arsenault; Megan  Coylewright; W. David  Merryman; David E Newby; John  Lewis; Frank E Harrell; Michael J.  Mack; Martin B.  Leon; Catherine M Otto; Philippe Pibarot

Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

Brian R. Lindman, Devraj Sukul, Marc R Dweck, Mahesh V. Madhavan, Benoit J Arsenault, Megan Coylewright, W. David Merryman, David E Newby, John Lewis, Frank E Harrell, Michael J. Mack, Martin B. Leon, Catherine M Otto, Philippe Pibarot

Research output: Contribution to journal › Review article › peer-review

Abstract

Progress in elucidating the pathobiology of aortic stenosis (AS) and identifying promising therapeutic targets has not yet translated into proven pharmacologic treatment for AS. This review offers practical guidance to address scientific, operational, and trial design challenges and proposes the development of a clinical trials research network to execute a platform trial as the optimal path to efficiently test multiple potential therapies to identify effective ones that can complement mechanical solutions for late-stage disease.

Original language	English
Journal	Journal of the American College of Cardiology
Publication status	Published - 7 Dec 2021

Embargoed Document

Evaluating Medical Therapy for Calcific AS - JACC SOA Review_revised manuscript_clean
Accepted author manuscript, 2.32 MB
Embargo ends: 7/12/22

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Lindman, Brian R. ; Sukul, Devraj ; Dweck, Marc R ; Madhavan, Mahesh V. ; Arsenault, Benoit J ; Coylewright, Megan ; Merryman, W. David ; Newby, David E ; Lewis, John ; Harrell, Frank E ; Mack, Michael J. ; Leon, Martin B. ; Otto, Catherine M ; Pibarot, Philippe. / Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review. In: Journal of the American College of Cardiology. 2021.

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title = "Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review",

abstract = "Progress in elucidating the pathobiology of aortic stenosis (AS) and identifying promising therapeutic targets has not yet translated into proven pharmacologic treatment for AS. This review offers practical guidance to address scientific, operational, and trial design challenges and proposes the development of a clinical trials research network to execute a platform trial as the optimal path to efficiently test multiple potential therapies to identify effective ones that can complement mechanical solutions for late-stage disease.",

author = "Lindman, {Brian R.} and Devraj Sukul and Dweck, {Marc R} and Madhavan, {Mahesh V.} and Arsenault, {Benoit J} and Megan Coylewright and Merryman, {W. David} and Newby, {David E} and John Lewis and Harrell, {Frank E} and Mack, {Michael J.} and Leon, {Martin B.} and Otto, {Catherine M} and Philippe Pibarot",

year = "2021",

month = dec,

day = "7",

language = "English",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "ELSEVIER SCIENCE INC",

}

Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review. / Lindman, Brian R. ; Sukul, Devraj ; Dweck, Marc R; Madhavan, Mahesh V. ; Arsenault, Benoit J; Coylewright, Megan ; Merryman, W. David ; Newby, David E; Lewis, John ; Harrell, Frank E; Mack, Michael J. ; Leon, Martin B. ; Otto, Catherine M; Pibarot, Philippe.

In: Journal of the American College of Cardiology, 07.12.2021.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

AU - Lindman, Brian R.

AU - Sukul, Devraj

AU - Dweck, Marc R

AU - Madhavan, Mahesh V.

AU - Arsenault, Benoit J

AU - Coylewright, Megan

AU - Merryman, W. David

AU - Newby, David E

AU - Lewis, John

AU - Harrell, Frank E

AU - Mack, Michael J.

AU - Leon, Martin B.

AU - Otto, Catherine M

AU - Pibarot, Philippe

PY - 2021/12/7

Y1 - 2021/12/7

N2 - Progress in elucidating the pathobiology of aortic stenosis (AS) and identifying promising therapeutic targets has not yet translated into proven pharmacologic treatment for AS. This review offers practical guidance to address scientific, operational, and trial design challenges and proposes the development of a clinical trials research network to execute a platform trial as the optimal path to efficiently test multiple potential therapies to identify effective ones that can complement mechanical solutions for late-stage disease.

AB - Progress in elucidating the pathobiology of aortic stenosis (AS) and identifying promising therapeutic targets has not yet translated into proven pharmacologic treatment for AS. This review offers practical guidance to address scientific, operational, and trial design challenges and proposes the development of a clinical trials research network to execute a platform trial as the optimal path to efficiently test multiple potential therapies to identify effective ones that can complement mechanical solutions for late-stage disease.

M3 - Review article

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

ER -

Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

Abstract

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