Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

Brian R. Lindman, Devraj Sukul, Marc R Dweck, Mahesh V. Madhavan, Benoit J Arsenault, Megan Coylewright, W. David Merryman, David E Newby, John Lewis, Frank E Harrell, Michael J. Mack, Martin B. Leon, Catherine M Otto, Philippe Pibarot

Research output: Contribution to journalReview articlepeer-review

Abstract

Progress in elucidating the pathobiology of aortic stenosis (AS) and identifying promising therapeutic targets has not yet translated into proven pharmacologic treatment for AS. This review offers practical guidance to address scientific, operational, and trial design challenges and proposes the development of a clinical trials research network to execute a platform trial as the optimal path to efficiently test multiple potential therapies to identify effective ones that can complement mechanical solutions for late-stage disease.
Original languageEnglish
JournalJournal of the American College of Cardiology
Publication statusPublished - 7 Dec 2021

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