Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (2008-2012)

Kathryn M. Pratschke, Matt J. Atherton, Jack A. Sillito, Catherine G. Lamm

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective-To evaluate a modified proportional margins approach to resection of mast cell tumors (MCTs) in dogs. Design-Retrospective case series. Animals-40 dogs with subcutaneous and cutaneous MCTs undergoing curative intent surgery. Procedures-Medical records were searched to identify dogs with a cytologically or histologically confirmed diagnosis of MCT that had not previously been treated surgically and that had undergone full oncological staging. In those dogs, tumors were resected with lateral margins equivalent to the widest measured diameter of the tumor and a minimum depth of 1 well-defined fascial plane deep to the tumor. Surgical margins were evaluated histologically. Cutaneous tumors were graded by use of the Patnaik system and the 2-tier system described by Kiupel et al. The prognosis for subcutaneous tumors was assessed in accordance with published recommendations. Follow-up information on dog health status was obtained through clinical examination, the dog owners, and the referring veterinarians. Results-The 40 dogs had 47 tumors. Forty-one (87%) tumors were cutaneous, and 6 (13%) were subcutaneous. On the basis of the Patnaik system, 21 (51%) cutaneous tumors were considered grade I, 18 (44%) were considered grade II, and 2 (5%) were considered grade III. On the basis of the Kiupel system, 37 (90%) cutaneous tumors were considered low grade, and 4 (10%) were considered high grade. The prognosis for the 6 subcutaneous tumors was classified as likely resulting in a shorter (2) or longer (4) survival time. Forty tumors were deemed to have been excised with clear margins and 7 with incomplete margins. Local recurrence was not recorded for any dog but was suspected for 1 (2%) tumor, although not confirmed. Interval from tumor excision to follow-up ranged from 30 to 1,140 days (median, 420 days). Conclusions and Clinical Relevance-The modified proportional margins system resulted in satisfactory local disease control in dogs with MCTs.

Original languageEnglish
Pages (from-to)1436-1441
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume243
Issue number10
DOIs
Publication statusPublished - 15 Nov 2013

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