Evaluation of a novel Doppler index of combined systolic and diastolic myocardial function (index of myocardial performance-IMP) in Newfoundland dogs with familial dilated cardiomyopathy

B-H Lee, J. Dukes-McEwan, A. French, Brendan Corcoran

Research output: Contribution to journalArticlepeer-review

Abstract

A Doppler index of myocardial performance (IMP) has been recently proposed in human cardiology, which is calculated from the isovolumic contraction time (ICT), isovolumic relaxation time (IRT), and the ejection time (ET) using the following formula: (ICT+IRT)/ET. In this study, IMP was measured and evaluated in Newfoundland dogs categorized in four groups: Normal dogs (n = 31), dilated cardiomyopathy (DCM) (n = 34), depressed fractional shortening (dFS) (n = 27), and left ventricular enlargement (LVE) (n = 7). IMP was found to be independent of age, sex, body surface area, and the R-R interval in the Normal group. There were significant differences in IMP between the DCM group and the Normal and dFS groups (P < 0.05) and between Newfoundlands with overt vs. occult DCM. IMP is a Doppler index which appears to correlate with severity of disease and may be of use in the early diagnosis of affected dogs during screening for the presence of DCM.
Original languageEnglish
Pages (from-to)154–165
Number of pages17
JournalVeterinary Radiology and Ultrasound
Volume43
Issue number2
DOIs
Publication statusPublished - Mar 2002

Keywords

  • Newfoundland dogs
  • familial dilated cardiomyopathy
  • echocardiography
  • systolic function
  • dilated cardiomyopathy
  • occult dilated cardiomyopathy
  • doppler index
  • diastolic function

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