Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting

Cyril Pernet; Gorgolewski Krzysztof; Dominic Job; David Rodriguez Gonzalez; Amos Storkey; Ian Whittle; Joanna Wardlaw

doi:10.1016/j.ijmedinf.2015.11.014

Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting

Cyril Pernet, Gorgolewski Krzysztof, Dominic Job, David Rodriguez Gonzalez, Amos Storkey, Ian Whittle, Joanna Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. Methods: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. Results: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). Conclusion: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.

Original language	English
Pages (from-to)	37-42
Number of pages	6
Journal	International journal of medical informatics
Volume	86
Early online date	30 Nov 2015
DOIs	https://doi.org/10.1016/j.ijmedinf.2015.11.014
Publication status	Published - Feb 2016

Keywords / Materials (for Non-textual outputs)

Protocol Development
Workflow
fMRI
surgical planning
Brain tumour

Access to Document

10.1016/j.ijmedinf.2015.11.014

2016_Pernet_al_IntJMedInf_.86_37-42
This is the author's final peer-reviewed manuscript as accepted for publication.
Accepted author manuscript, 682 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

http://www.sciencedirect.com/science/article/pii/S1386505615300654

1 Conference contribution
1 Article

Adaptive thresholding for reliable topological inference in single subject fMRI analysis
Gorgolewski, K. J., Storkey, A. J., Bastin, M. E. & Pernet, C. R., 25 Aug 2012, In: Frontiers in Human Neuroscience. 6, 245.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Reliability of single subject fMRI in the context of presurgical planning
Gorgolewski, K. J., Storkey, A., Bastin, M. & Pernet, C., 2012, 18th Annual Meeting of the Organization for Human Brain Mapping.
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Invited talk

Making fMRI for brain tumours a routine clinical tool: issues and applications
Pernet, C. (Invited speaker)
28 Apr 2016
Activity: Academic talk or presentation types › Invited talk

Cyril Pernet
Person: Academic: Research Active

Cite this

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title = "Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting",

abstract = "Purpose: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. Methods: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. Results: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). Conclusion: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.",

keywords = "Protocol Development, Workflow, fMRI, surgical planning, Brain tumour",

author = "Cyril Pernet and Gorgolewski Krzysztof and Dominic Job and {Rodriguez Gonzalez}, David and Amos Storkey and Ian Whittle and Joanna Wardlaw",

year = "2016",

month = feb,

doi = "10.1016/j.ijmedinf.2015.11.014",

language = "English",

volume = "86",

pages = "37--42",

journal = "International journal of medical informatics",

issn = "1386-5056",

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T1 - Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting

AU - Pernet, Cyril

AU - Krzysztof, Gorgolewski

AU - Job, Dominic

AU - Rodriguez Gonzalez, David

AU - Storkey, Amos

AU - Whittle, Ian

AU - Wardlaw, Joanna

PY - 2016/2

Y1 - 2016/2

N2 - Purpose: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. Methods: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. Results: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). Conclusion: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.

AB - Purpose: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. Methods: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. Results: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). Conclusion: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.

KW - Protocol Development

KW - Workflow

KW - fMRI

KW - surgical planning

KW - Brain tumour

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DO - 10.1016/j.ijmedinf.2015.11.014

M3 - Article

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JO - International journal of medical informatics

JF - International journal of medical informatics

ER -

Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting

Abstract

Keywords / Materials (for Non-textual outputs)

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Research output

Adaptive thresholding for reliable topological inference in single subject fMRI analysis

Reliability of single subject fMRI in the context of presurgical planning

Activities

Making fMRI for brain tumours a routine clinical tool: issues and applications

Profiles

Cyril Pernet

Cite this