Evaluation of ADAM-12 as a diagnostic biomarker of ectopic pregnancy in women with a pregnancy of unknown location

Andrew W Horne, Jeremy K Brown, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Research output: Contribution to journalArticlepeer-review

Abstract

Ectopic pregnancy (EP) remains the most life-threatening acute condition in modern gynaecology. It remains difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL) and diagnosis/exclusion of EP is challenging due to a lack of reliable biomarkers. Recent studies suggest that serum levels of a disintegrin and metalloprotease protein-12 (ADAM-12) can be used differentiate EP from viable intrauterine pregnancy (VIUP). Here we describe a prospective study evaluating the performance of ADAM-12 in differentiating EP from the full spectrum of alternative PUL outcomes in an independent patient cohort.
Original languageEnglish
Pages (from-to)e41442
JournalPLoS ONE
Volume7
Issue number8
DOIs
Publication statusPublished - 2012

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