Abstract
Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.
| Original language | English |
|---|---|
| Pages (from-to) | 183-5 |
| Number of pages | 3 |
| Journal | British Journal of Cancer |
| Volume | 69 |
| Issue number | 1 |
| Publication status | Published - Jan 1994 |
Keywords / Materials (for Non-textual outputs)
- Adult
- Aged
- Breast Neoplasms
- Carcinoma in Situ
- Carcinoma, Ductal, Breast
- Evaluation Studies as Topic
- Female
- Follow-Up Studies
- Gene Expression
- Glutathione Transferase
- Humans
- Immunohistochemistry
- Isoenzymes
- Middle Aged
- Proto-Oncogene Proteins
- Receptor, Epidermal Growth Factor
- Receptor, erbB-2