Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast

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Abstract

Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive.
Original languageEnglish
Pages (from-to)183-5
Number of pages3
JournalBritish Journal of Cancer
Volume69
Issue number1
Publication statusPublished - Jan 1994

Keywords

  • Adult
  • Aged
  • Breast Neoplasms
  • Carcinoma in Situ
  • Carcinoma, Ductal, Breast
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Gene Expression
  • Glutathione Transferase
  • Humans
  • Immunohistochemistry
  • Isoenzymes
  • Middle Aged
  • Proto-Oncogene Proteins
  • Receptor, Epidermal Growth Factor
  • Receptor, erbB-2

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