Evaluation of platelet activation in canine immune-mediated haemolytic anaemia

A.E. Ridyard, D.J. Shaw, Elspeth Milne

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Methods: Using whole-blood flow-cytometric analysis, the proportion of activated platelets and platelet-leucocyte aggregates in blood samples from 14 dogs with immune-mediated haemolytic anaemia and 14 healthy dogs was calculated. General linear models with binomial errors were used to compare groups. Results from the immune-mediated haemolytic anaemia-affected dogs were then correlated with established risk factors for thromboembolism in canine immune-mediated haemolytic anaemia, D-dimer concentration and antithrombin activity. Results: There was a strong correlation between platelet activation and severe thrombocytopenia, with heightened platelet activation being observed predominantly in severely thrombocytopenic dogs. Clinical Significance: Dogs with immune-mediated haemolytic anaemia, particularly those with concurrent severe thrombocytopenia, are likely to have heightened platelet activation, which may play a role in the pathogenesis of thromboembolism.
Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalJournal of Small Animal Practice
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 2010

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