Evaluation of three 3ABC ELISAs for foot-and-mouth disease non-structural antibodies using latent class analysis

Mark Bronsvoort, Nils Toft, Ingrid E Bergmann, Karl-Johan Sørensen, John Anderson, Viviane Malirat, Vincent N Tanya, Kenton L Morgan

Research output: Contribution to journalArticlepeer-review

Abstract

Foot-and-mouth disease (FMD) is a highly contagious viral disease of even-toed ungulates. Serological diagnosis/surveillance of FMD presents several problems as there are seven serotypes worldwide and in the event of vaccination it may be necessary to be able to identify FMD infected/exposed animals irrespective of their vaccination status. The recent development of non-structural 3ABC protein (NSP) ELISA tests has greatly advanced sero-diagnosis/surveillance as these tests detect exposure to live virus for any of the seven serotypes of FMD, even in vaccinated populations. This paper analyses the performance of three NSP tests using a Bayesian formulation of the Hui-Walter latent class model to estimate test sensitivity and specificity in the absence of a "gold-standard" test, using sera from a well described cattle population in Cameroon with endemic FMD.
Original languageEnglish
Pages (from-to)30
JournalBMC Veterinary Research
Volume2
DOIs
Publication statusPublished - 2006

Keywords

  • Aging
  • Animals
  • Antibodies, Viral
  • Cameroon
  • Cattle
  • Cattle Diseases
  • Enzyme-Linked Immunosorbent Assay
  • Foot-and-Mouth Disease
  • Sensitivity and Specificity

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