Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

Hannah K Long, Sara L Prescott, Joanna Wysocka

Research output: Contribution to journalReview articlepeer-review

Abstract

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important mediator of inter- and intra-species phenotypic variation. Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution, and the influence of three-dimensional genome organization on long-range gene regulation. We discuss intricate relationships between distinct elements within complex regulatory landscapes and consider their potential impact on specificity and robustness of transcriptional regulation.

Original languageEnglish
Pages (from-to)1170-1187
Number of pages18
JournalCell
Volume167
Issue number5
DOIs
Publication statusPublished - 17 Nov 2016

Keywords

  • Blood/metabolism
  • Blood Cells/metabolism
  • Enhancer Elements, Genetic
  • Epigenomics
  • Evolution, Molecular
  • Genome-Wide Association Study
  • Hematopoiesis
  • Humans
  • Quantitative Trait Loci
  • Transcription, Genetic

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