Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis

J J Powell, K C Fearon, A K Siriwardena, J A Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and their endogenous antagonists such as IL-1 receptor antagonist (IL-1RA) are important mediators of disease severity in acute pancreatitis. Because the level of secretion of these cytokines is determined in part by genetic factors, the aim of this study was to examine the influence of genetically determined cytokine secretion upon disease severity in acute pancreatitis.
Original languageEnglish
Pages (from-to)633-40
Number of pages8
JournalSurgery
Volume129
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint Dive into the research topics of 'Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis'. Together they form a unique fingerprint.

Cite this