Evidence for an age-related influence of microsatellite instability on colorectal cancer survival

Susan M Farrington, Aileen J McKinley, Andrew D Carothers, Christopher Cunningham, Vivien J Bubb, Linda Sharp, Andrew H Wyllie, Malcolm G Dunlop

Research output: Contribution to journalArticlepeer-review

Abstract

It is well established that microsatellite instability (MSI), the hallmark of defective DNA mismatch repair (MMR), is associated with prolonged survival in colorectal cancer compared with tumours that are microsatellite stable (MSS). MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. However, there are no prospective population-based studies of survival in patients with germline MMR gene mutations who develop cancer. Although MSI is almost universal in tumours from HNPCC family members, there is a potential confounding effect of ascertainment and other biases that could explain the apparent survival benefit in HNPCC families. Resolving whether germline MMR gene mutations impact on survival is important because it potentially undermines the rationale for surveillance of mutation carriers. Here, we report an investigation of the influence of MSI on survival in cohorts of cancer patients (aged
Original languageEnglish
Pages (from-to)844-50
Number of pages7
JournalInternational Journal of Cancer
Volume98
Issue number6
Publication statusPublished - 20 Apr 2002

Keywords

  • Adaptor Proteins, Signal Transducing
  • Adenocarcinoma, Mucinous
  • Adult
  • Age Factors
  • Base Pair Mismatch
  • Carrier Proteins
  • Cohort Studies
  • Colorectal Neoplasms
  • DNA Repair
  • DNA-Binding Proteins
  • Female
  • Germ-Line Mutation
  • Humans
  • Male
  • Microsatellite Repeats
  • MutS Homolog 2 Protein
  • Neoplasm Proteins
  • Neoplasm Staging
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Survival Rate
  • Time Factors

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