Evidence for an age-related influence of microsatellite instability on colorectal cancer survival

Susan M Farrington; Aileen J McKinley; Andrew D Carothers; Christopher Cunningham; Vivien J Bubb; Linda Sharp; Andrew H Wyllie; Malcolm G Dunlop

Evidence for an age-related influence of microsatellite instability on colorectal cancer survival

Susan M Farrington, Aileen J McKinley, Andrew D Carothers, Christopher Cunningham, Vivien J Bubb, Linda Sharp, Andrew H Wyllie, Malcolm G Dunlop

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

It is well established that microsatellite instability (MSI), the hallmark of defective DNA mismatch repair (MMR), is associated with prolonged survival in colorectal cancer compared with tumours that are microsatellite stable (MSS). MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. However, there are no prospective population-based studies of survival in patients with germline MMR gene mutations who develop cancer. Although MSI is almost universal in tumours from HNPCC family members, there is a potential confounding effect of ascertainment and other biases that could explain the apparent survival benefit in HNPCC families. Resolving whether germline MMR gene mutations impact on survival is important because it potentially undermines the rationale for surveillance of mutation carriers. Here, we report an investigation of the influence of MSI on survival in cohorts of cancer patients (aged

Original language	English
Pages (from-to)	844-50
Number of pages	7
Journal	International Journal of Cancer
Volume	98
Issue number	6
Publication status	Published - 20 Apr 2002

Keywords / Materials (for Non-textual outputs)

Adaptor Proteins, Signal Transducing
Adenocarcinoma, Mucinous
Adult
Age Factors
Base Pair Mismatch
Carrier Proteins
Cohort Studies
Colorectal Neoplasms
DNA Repair
DNA-Binding Proteins
Female
Germ-Line Mutation
Humans
Male
Microsatellite Repeats
MutS Homolog 2 Protein
Neoplasm Proteins
Neoplasm Staging
Nuclear Proteins
Proto-Oncogene Proteins
Survival Rate
Time Factors

Cite this

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title = "Evidence for an age-related influence of microsatellite instability on colorectal cancer survival",

abstract = "It is well established that microsatellite instability (MSI), the hallmark of defective DNA mismatch repair (MMR), is associated with prolonged survival in colorectal cancer compared with tumours that are microsatellite stable (MSS). MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. However, there are no prospective population-based studies of survival in patients with germline MMR gene mutations who develop cancer. Although MSI is almost universal in tumours from HNPCC family members, there is a potential confounding effect of ascertainment and other biases that could explain the apparent survival benefit in HNPCC families. Resolving whether germline MMR gene mutations impact on survival is important because it potentially undermines the rationale for surveillance of mutation carriers. Here, we report an investigation of the influence of MSI on survival in cohorts of cancer patients (aged ",

keywords = "Adaptor Proteins, Signal Transducing, Adenocarcinoma, Mucinous, Adult, Age Factors, Base Pair Mismatch, Carrier Proteins, Cohort Studies, Colorectal Neoplasms, DNA Repair, DNA-Binding Proteins, Female, Germ-Line Mutation, Humans, Male, Microsatellite Repeats, MutS Homolog 2 Protein, Neoplasm Proteins, Neoplasm Staging, Nuclear Proteins, Proto-Oncogene Proteins, Survival Rate, Time Factors",

author = "Farrington, {Susan M} and McKinley, {Aileen J} and Carothers, {Andrew D} and Christopher Cunningham and Bubb, {Vivien J} and Linda Sharp and Wyllie, {Andrew H} and Dunlop, {Malcolm G}",

year = "2002",

month = apr,

day = "20",

language = "English",

volume = "98",

pages = "844--50",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

number = "6",

}

TY - JOUR

T1 - Evidence for an age-related influence of microsatellite instability on colorectal cancer survival

AU - Farrington, Susan M

AU - McKinley, Aileen J

AU - Carothers, Andrew D

AU - Cunningham, Christopher

AU - Bubb, Vivien J

AU - Sharp, Linda

AU - Wyllie, Andrew H

AU - Dunlop, Malcolm G

PY - 2002/4/20

Y1 - 2002/4/20

N2 - It is well established that microsatellite instability (MSI), the hallmark of defective DNA mismatch repair (MMR), is associated with prolonged survival in colorectal cancer compared with tumours that are microsatellite stable (MSS). MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. However, there are no prospective population-based studies of survival in patients with germline MMR gene mutations who develop cancer. Although MSI is almost universal in tumours from HNPCC family members, there is a potential confounding effect of ascertainment and other biases that could explain the apparent survival benefit in HNPCC families. Resolving whether germline MMR gene mutations impact on survival is important because it potentially undermines the rationale for surveillance of mutation carriers. Here, we report an investigation of the influence of MSI on survival in cohorts of cancer patients (aged

AB - It is well established that microsatellite instability (MSI), the hallmark of defective DNA mismatch repair (MMR), is associated with prolonged survival in colorectal cancer compared with tumours that are microsatellite stable (MSS). MSI in sporadic colorectal tumours is primarily due to epigenetic silencing of MLH1. However, there are no prospective population-based studies of survival in patients with germline MMR gene mutations who develop cancer. Although MSI is almost universal in tumours from HNPCC family members, there is a potential confounding effect of ascertainment and other biases that could explain the apparent survival benefit in HNPCC families. Resolving whether germline MMR gene mutations impact on survival is important because it potentially undermines the rationale for surveillance of mutation carriers. Here, we report an investigation of the influence of MSI on survival in cohorts of cancer patients (aged

KW - Adaptor Proteins, Signal Transducing

KW - Adenocarcinoma, Mucinous

KW - Adult

KW - Age Factors

KW - Base Pair Mismatch

KW - Carrier Proteins

KW - Cohort Studies

KW - Colorectal Neoplasms

KW - DNA Repair

KW - DNA-Binding Proteins

KW - Female

KW - Germ-Line Mutation

KW - Humans

KW - Male

KW - Microsatellite Repeats

KW - MutS Homolog 2 Protein

KW - Neoplasm Proteins

KW - Neoplasm Staging

KW - Nuclear Proteins

KW - Proto-Oncogene Proteins

KW - Survival Rate

KW - Time Factors

M3 - Article

C2 - 11948461

SN - 0020-7136

VL - 98

SP - 844

EP - 850

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 6

ER -

Evidence for an age-related influence of microsatellite instability on colorectal cancer survival

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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