Evidence for strain specificity in cytotoxic T-lymphocyte-mediated, major histocompatibility complex class I-dependent killing of Theileria annulata-infected cells

G Conze, JDM Campbell, AK Nichani, EJ Glass, RL Spooner, JS Ahmed*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cattle immunised against Theileria annulata with one parasite strain have been found to be immune to re-challenge with different strains of the parasite. However, recent evidence of apparent strain specificity has been documented in cattle immunised with attenuated parasite-infected cells. In this study the strain specificity of major histocompatibility complex class I-restricted cytotoxic T-lymphocytes (CTL), a major anti-parasite effector mechanism, was examined. CTL generated following challenge with the Hissar (Indian) strain effectively lysed autologous cells infected with this strain of the parasite. However, CTL were less effective against cells infected with the Gharb (Moroccan) strain and showed virtually no reactivity against the Ankara (Turkish) strain, providing the first direct evidence for strain specificity in immune responses against T. annulata.

Original languageEnglish
Pages (from-to)593-595
Number of pages3
JournalParasitology Research
Volume84
Issue number7
Publication statusPublished - Jul 1998

Keywords

  • CATTLE
  • DSCHUNKOWSKY
  • LUHS

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