Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily

E Schröder, C P Ponting

Research output: Contribution to journalArticlepeer-review

Abstract

Peroxiredoxins catalyze reduction of hydrogen peroxide or alkyl peroxide, to water or the corresponding alcohol. Detailed analysis of their sequences indicates that these enzymes possess a thioredoxin (Trx)-like fold and consequently are homologues of both thioredoxin and glutathione peroxidase (GPx). Sequence- and structure-based multiple sequence alignments indicate that the peroxiredoxin active site cysteine and GPx active site selenocysteine are structurally equivalent. Homologous peroxiredoxin and GPx enzymes are predicted to catalyze equivalent reactions via similar reaction intermediates.

Original languageEnglish
Pages (from-to)2465-8
Number of pages4
JournalProtein Science
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 1998

Keywords

  • Amino Acid Sequence
  • Antioxidants
  • Binding Sites
  • Catalysis
  • Cysteine
  • Glutathione Peroxidase
  • Molecular Sequence Data
  • Oxidation-Reduction
  • Peroxidases
  • Peroxiredoxins
  • Protein Folding
  • Selenocysteine
  • Sequence Alignment
  • Thioredoxins

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