Evolution and functions of long noncoding RNAs

Chris P Ponting, Peter L Oliver, Wolf Reik

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.

Original languageEnglish
Pages (from-to)629-41
Number of pages13
JournalCell
Volume136
Issue number4
DOIs
Publication statusPublished - 20 Feb 2009

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Evolution, Molecular
  • Gene Expression Regulation
  • Humans
  • RNA, Untranslated

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