Evolution and functions of long noncoding RNAs

Chris P Ponting; Peter L Oliver; Wolf Reik

doi:10.1016/j.cell.2009.02.006

Evolution and functions of long noncoding RNAs

Chris P Ponting, Peter L Oliver, Wolf Reik

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.

Original language	English
Pages (from-to)	629-41
Number of pages	13
Journal	Cell
Volume	136
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.02.006
Publication status	Published - 20 Feb 2009

Keywords / Materials (for Non-textual outputs)

Animals
Evolution, Molecular
Gene Expression Regulation
Humans
RNA, Untranslated

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10.1016/j.cell.2009.02.006

Cite this

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AB - RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.

KW - Animals

KW - Evolution, Molecular

KW - Gene Expression Regulation

KW - Humans

KW - RNA, Untranslated

U2 - 10.1016/j.cell.2009.02.006

DO - 10.1016/j.cell.2009.02.006

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JO - Cell

JF - Cell

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Evolution and functions of long noncoding RNAs

Abstract

Keywords / Materials (for Non-textual outputs)

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