Evolution of Drug Resistance in Bacteria

Bartlomiej Waclaw

doi:10.1007/978-3-319-32189-9_5

Evolution of Drug Resistance in Bacteria

Bartlomiej Waclaw

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Resistance to antibiotics is an important and timely problem of contemporary medicine. Rapid evolution of resistant bacteria calls for new preventive measures to slow down this process, and a longer-term progress cannot be achieved without a good understanding of the mechanisms through which drug resistance is acquired and spreads in microbial populations. Here, we discuss recent experimental and theoretical advances in our knowledge how the dynamics of microbial populations affects the evolution of antibiotic resistance . We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections.

Original language	English
Title of host publication	Biophysics of infection
Editors	Mark C. Leake
Publisher	Springer
Pages	49-67
Number of pages	19
Volume	915
Edition	1
ISBN (Electronic)	978-3-319-32189-9
ISBN (Print)	978-3-319-32187-5
DOIs	https://doi.org/10.1007/978-3-319-32189-9_5
Publication status	Published - 19 May 2016

Publication series

Name	Advances in Experimental Medicine and Biology
Publisher	SPRINGER-VERLAG BERLIN
Volume	915
ISSN (Print)	0065-2598

Keywords / Materials (for Non-textual outputs)

Antibiotic resistance
Modelling infection
Biological evolution
ANTIBIOTIC-RESISTANCE
PSEUDOMONAS-AERUGINOSA
CYSTIC-FIBROSIS
TISSUE PENETRATION
ESCHERICHIA-COLI
CIPROFLOXACIN THERAPY
STAPHYLOCOCCUS-AUREUS
MUTATION-RATES
LUNG INFECTION
MECHANISMS

Access to Document

10.1007/978-3-319-32189-9_5

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Cite this

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title = "Evolution of Drug Resistance in Bacteria",

abstract = "Resistance to antibiotics is an important and timely problem of contemporary medicine. Rapid evolution of resistant bacteria calls for new preventive measures to slow down this process, and a longer-term progress cannot be achieved without a good understanding of the mechanisms through which drug resistance is acquired and spreads in microbial populations. Here, we discuss recent experimental and theoretical advances in our knowledge how the dynamics of microbial populations affects the evolution of antibiotic resistance . We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections.",

keywords = "Antibiotic resistance, Modelling infection, Biological evolution, ANTIBIOTIC-RESISTANCE, PSEUDOMONAS-AERUGINOSA, CYSTIC-FIBROSIS, TISSUE PENETRATION, ESCHERICHIA-COLI, CIPROFLOXACIN THERAPY, STAPHYLOCOCCUS-AUREUS, MUTATION-RATES, LUNG INFECTION, MECHANISMS",

author = "Bartlomiej Waclaw",

year = "2016",

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doi = "10.1007/978-3-319-32189-9_5",

language = "English",

isbn = "978-3-319-32187-5 ",

volume = "915",

series = "Advances in Experimental Medicine and Biology",

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T1 - Evolution of Drug Resistance in Bacteria

AU - Waclaw, Bartlomiej

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Y1 - 2016/5/19

N2 - Resistance to antibiotics is an important and timely problem of contemporary medicine. Rapid evolution of resistant bacteria calls for new preventive measures to slow down this process, and a longer-term progress cannot be achieved without a good understanding of the mechanisms through which drug resistance is acquired and spreads in microbial populations. Here, we discuss recent experimental and theoretical advances in our knowledge how the dynamics of microbial populations affects the evolution of antibiotic resistance . We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections.

AB - Resistance to antibiotics is an important and timely problem of contemporary medicine. Rapid evolution of resistant bacteria calls for new preventive measures to slow down this process, and a longer-term progress cannot be achieved without a good understanding of the mechanisms through which drug resistance is acquired and spreads in microbial populations. Here, we discuss recent experimental and theoretical advances in our knowledge how the dynamics of microbial populations affects the evolution of antibiotic resistance . We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections.

KW - Antibiotic resistance

KW - Modelling infection

KW - Biological evolution

KW - ANTIBIOTIC-RESISTANCE

KW - PSEUDOMONAS-AERUGINOSA

KW - CYSTIC-FIBROSIS

KW - TISSUE PENETRATION

KW - ESCHERICHIA-COLI

KW - CIPROFLOXACIN THERAPY

KW - STAPHYLOCOCCUS-AUREUS

KW - MUTATION-RATES

KW - LUNG INFECTION

KW - MECHANISMS

U2 - 10.1007/978-3-319-32189-9_5

DO - 10.1007/978-3-319-32189-9_5

M3 - Chapter

SN - 978-3-319-32187-5

VL - 915

T3 - Advances in Experimental Medicine and Biology

SP - 49

EP - 67

BT - Biophysics of infection

A2 - Leake, Mark C.

PB - Springer

ER -

Evolution of Drug Resistance in Bacteria

Abstract

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Keywords / Materials (for Non-textual outputs)

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