Evolution of genes and genomes on the Drosophila phylogeny

Drosophila 12 Genomes Consortium, Andrew G Clark, Michael B Eisen, Douglas R Smith, Casey M Bergman, Brian Oliver, Therese A Markow, Thomas C Kaufman, Manolis Kellis, William Gelbart, Venky N Iyer, Daniel A Pollard, Timothy B Sackton, Amanda M Larracuente, Nadia D Singh, Jose P Abad, Dawn N Abt, Boris Adryan, Montserrat Aguade, Hiroshi AkashiWyatt W Anderson, Charles F Aquadro, David H Ardell, Roman Arguello, Carlo G Artieri, Daniel A Barbash, Daniel Barker, Paolo Barsanti, Phil Batterham, Serafim Batzoglou, Dave Begun, Arjun Bhutkar, Enrico Blanco, Stephanie A Bosak, Robert K Bradley, Adrianne D Brand, Michael R Brent, Angela N Brooks, Randall H Brown, Roger K Butlin, Corrado Caggese, Brian R Calvi, A Bernardo de Carvalho, Anat Caspi, Sergio Castrezana, Daniel L Halligan, Peter D Keightley, Sudhir Kumar, Chris P Ponting, Andrew Barry, Charles Matthews

Research output: Contribution to journalArticlepeer-review

Abstract

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

Original languageEnglish
Pages (from-to)203-218
Number of pages16
JournalNature
Volume450
Issue number7167
DOIs
Publication statusPublished - 8 Nov 2007

Keywords

  • Animals
  • Codon
  • DNA Transposable Elements
  • Drosophila
  • Drosophila Proteins
  • Evolution, Molecular
  • Gene Order
  • Genes, Insect
  • Genome, Insect
  • Genome, Mitochondrial
  • Genomics
  • Immunity
  • Multigene Family
  • Phylogeny
  • RNA, Untranslated
  • Reproduction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Synteny

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