EVOLUTION OF THE SERUM AMYLOID-A (SAA) PROTEIN SUPERFAMILY

CM UHLAR, CJ BURGESS, Paul M. Sharp, AS WHITEHEAD

Research output: Contribution to journalArticlepeer-review

Abstract

The serum amyloid A (SAA) superfamily comprises a number of genes and proteins characterized from a range of mammalian species. The majority of members described to date are dramatically induced during the acute-phase response, suggesting an important shortterm beneficial role in the response to tissue injury and inflammation. However, important disease associations have also been proposed for certain SAAs during chronic inflammation. The nomenclature of many of the superfamily members has been the result of comparisons with previously reported sequences implying disease association and/or functional relatedness between such members. The evolutionary relationships of the SAA superfamily members have been investigated by comparisons at both the amino acid and the nucleotide level. The results indicate that all members of the superfamily within a species have been undergoing concerted evolution. This has important implications in ascribing functions and disease associations to individual SAA superfamily members and indicates that designations should not be based on the extent of amino acid identity alone but should be made only following direct experimental observation of the proteins themselves. (C) 1991 Academic Press, Inc.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalGenomics
Volume19
Issue number2
Publication statusPublished - 15 Jan 1994

Keywords

  • NUCLEOTIDE-SEQUENCE
  • MESSENGER-RNAS
  • HIGH-DENSITY-LIPOPROTEIN
  • RABBIT
  • A GENE FAMILY
  • MOLECULAR CLOCK
  • CDNA SEQUENCES
  • AMINO-ACID-SEQUENCE
  • EXPRESSION
  • COMPLEMENTARY-DNA

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