Abstract
PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted X open reading frame (X-ORF) in segment 3. We show that the X-ORFs of diverse influenza A viruses can be divided into two groups that differ in selection pressure and likely function, reflected in the presence of an internal stop codon and a change in synonymous diversity. Notably, truncated forms of PA-X evolved convergently in swine and dogs, suggesting a strong species-specific effect.
Original language | English |
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Pages (from-to) | 12411-12413 |
Number of pages | 3 |
Journal | Journal of Virology |
Volume | 86 |
Issue number | 22 |
DOIs | |
Publication status | Published - Nov 2012 |