Evolutionary ecology of microbial wars: within-host competition and (incidental) virulence

Sam P. Brown, R. Fredrik Inglis, Francois Taddei

Research output: Contribution to journalArticlepeer-review

Abstract

Invading an occupied niche is a formidable ecological challenge, and one of particular human importance in the context of food-borne microbial pathogens. We discuss distinct categories of invader-triggered environmental change that facilitate invasion by emptying their niche of competitors. Evidence is reviewed that gut bacteria use such strategies to manipulate their environment (via bacteriocins, temperate phage viruses or immuno-manipulation) at the expense of their competitors are reviewed. The possible virulence implications of microbial warfare among multiple co-infecting strains are diverse. Killing competitors can reduce virulence by reducing overall microbial densities, or increase virulence if for example the allelopathic mechanism involves immuno-manipulation. Finally, we place microbial anti-competitor strategies in a social evolution framework, highlighting how costly anti-competitor strategies can be understood as examples of microbial spite. We conclude by discussing other invasive species that have also developed such proactive strategies of invasion.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalEvolutionary Applications
Volume2
Issue number1
Early online date7 Jan 2009
DOIs
Publication statusPublished - Feb 2009

Keywords

  • disease biology
  • evolutionary biology
  • microbial biology
  • social evolution
  • virulence

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