Evolving pharmacology of orphan GPCRs: IUPHAR Commentary

Anthony P. Davenport*, Anthony J. Harmar

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

Abstract

The award of the 2012 Nobel Prize in Chemistry to Robert Lefkowitz and Brian Kobilka for their work on the structure and function of GPCRs, spanning a period of more than 20years from the cloning of the human (2)-adrenoceptor to determining the crystal structure of the same protein, has earned both researchers a much deserved place in the pantheon of major scientific discoveries. GPCRs comprise one of the largest families of proteins, controlling many major physiological processes and have been a major focus of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) since its inception in 1987. We report here recent efforts by the British Pharmacological Society and NC-IUPHAR to define the endogenous ligands of orphan' GPCRs and to place authoritative and accessible information about these crucial therapeutic targets online.

Original languageEnglish
Pages (from-to)693-695
Number of pages3
JournalBritish Journal of Pharmacology
Volume170
Issue number4
DOIs
Publication statusPublished - Oct 2013

Keywords

  • chemerin receptor
  • chemokine receptors
  • free fatty acid receptors
  • hydroxycarboxylic acid receptors
  • lysophosphatidic acid receptors
  • oxoglutarate receptor
  • succinate receptor
  • PROTEIN-COUPLED RECEPTOR
  • INTERNATIONAL UNION
  • CRYSTAL-STRUCTURE
  • 5TH EDITION
  • GUIDETOPHARMACOLOGY.ORG
  • CHANNELS
  • DATABASE
  • LIGANDS
  • GUIDE
  • ISSUE

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