TY - JOUR
T1 - Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis
AU - Moss, Alastair J
AU - Sim, Alisia
AU - Adamson, Philip D
AU - Seidman, Michael A.
AU - Andrews, Jack
AU - Doris, Mhairi
AU - Shah, Anoop
AU - Bouhaidar, Ralph
AU - Alcaide-corral, Carlos José
AU - Williams, Michelle C
AU - Leipsic, Jonathon A.
AU - Dweck, Marc R
AU - MacRae, Vicky
AU - Newby, David E
AU - Tavares, Adriana A S
AU - Sellers, Stephanie L
PY - 2020/11/19
Y1 - 2020/11/19
N2 - Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.
AB - Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.
U2 - 10.1038/s41598-020-77391-6
DO - 10.1038/s41598-020-77391-6
M3 - Article
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
ER -