Exact solution of a model DNA-inversion genetic switch with orientational control

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Abstract

DNA inversion is an important mechanism by which bacteria and bacteriophage switch reversibly between phenotypic states. In such switches, the orientation of a short DNA element is flipped by a site-specific recombinase enzyme. We propose a simple model for a DNA-inversion switch in which recombinase production is dependent on the switch state (orientational control). Our model is inspired by the fim switch in E. coli. We present an exact analytical solution of the chemical master equation for the model switch, as well as stochastic simulations. Orientational control causes the switch to deviate from Poissonian behavior: the distribution of times in the on state shows a peak and successive flip times are correlated.

Original languageEnglish
Article number118104
Pages (from-to)-
Number of pages4
JournalPhysical Review Letters
Volume101
Issue number11
DOIs
Publication statusPublished - 12 Sep 2008

Keywords

  • ESCHERICHIA-COLI
  • PHASE VARIATION
  • EXPRESSION
  • BACTERIA
  • FIME

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