Excitation wave propagation in a patterned multidomain cardiac tissue

Nina Kudryashova, A. S. Teplenin, Y. V. Orlova, K. I. Agladze*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Electrospun fibrous mats are widely used in the contemporary cardiac tissue engineering as the substrates for growing cardiac cells. The substrate with chaotically oriented nanofibers leads to the growth of cardiac tissue with randomly oriented, but internally morphologically anisotropic clusters or domains. The domain structure affects the stability of the excitation propagation and we studied the stability of the propagating excitation waves versus the average size of the domains and the externally applied excitation rate. In an experimental model based on neonatal rat cardiac tissue monolayers, as well as in the computer simulations, we have found that an increase in domain sizes leads to the decrease in the critical stimulation frequencies, thus evidencing that larger domains are having a higher arrhythmogenic effect.

Original languageEnglish
Pages (from-to)772-775
Number of pages4
JournalJETP Letters
Volume101
Issue number11
DOIs
Publication statusPublished - 17 Jun 2015
Externally publishedYes

Keywords

  • Domain Size
  • Cardiac Tissue
  • Excitation Wave
  • Anistropy Ratio

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