Exclusion of adrenoceptor alpha 2 variants in a horse insensitive to medetomidine

Isabelle Schmutz, Vidhya Jagannathan, Sabina Diez Bernal, Simone Lanz, Ted Kalbfleisch, Tosso Leeb, Claudia Spadavecchia

Research output: Contribution to journalComment/debatepeer-review

Abstract

Patients may react in different ways to drugs, and genetic factors have to be considered when observing variability in drug responses.2008 Drugs acting as agonists for the alpha 2 adrenoceptor (formerly called α 2 adrenergic receptor), such as xylazine, detomidine, medetomidine and romifidine, are regularly used for sedation, premedication and analgesia in veterinary medicine.1995, 1996 Three genes encode for separate subtypes of alpha 2 adrenoceptors: ADRA2A , ADRA2B and ADRA2C .1994 Alpha 2 adrenoceptors modulate the regulation of blood pressure, renal function, insulin release, cognition, memory and behaviour.2005 Adra2a mutant mice (α 2AD79N) are resistant to sedation with dexmedetomidine.1999, 1997
Original languageEnglish
Pages (from-to)141
JournalAnimal Genetics
Volume49
Issue number2
Early online date23 Jan 2018
DOIs
Publication statusPublished - 13 Mar 2018

Keywords / Materials (for Non-textual outputs)

  • Adrenergic alpha-2 Receptor Agonists/administration & dosage
  • Animals
  • Anorexia/veterinary
  • Drug Resistance
  • Horses/genetics
  • Medetomidine/administration & dosage
  • Receptors, Adrenergic, alpha-2/genetics
  • Sequence Analysis, DNA

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