Abstract
Patients may react in different ways to drugs, and genetic factors have to be considered when observing variability in drug responses.2008 Drugs acting as agonists for the alpha 2 adrenoceptor (formerly called α 2 adrenergic receptor), such as xylazine, detomidine, medetomidine and romifidine, are regularly used for sedation, premedication and analgesia in veterinary medicine.1995, 1996 Three genes encode for separate subtypes of alpha 2 adrenoceptors: ADRA2A , ADRA2B and ADRA2C .1994 Alpha 2 adrenoceptors modulate the regulation of blood pressure, renal function, insulin release, cognition, memory and behaviour.2005 Adra2a mutant mice (α 2AD79N) are resistant to sedation with dexmedetomidine.1999, 1997
Original language | English |
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Pages (from-to) | 141 |
Journal | Animal Genetics |
Volume | 49 |
Issue number | 2 |
Early online date | 23 Jan 2018 |
DOIs |
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Publication status | Published - 13 Mar 2018 |
Keywords / Materials (for Non-textual outputs)
- Adrenergic alpha-2 Receptor Agonists/administration & dosage
- Animals
- Anorexia/veterinary
- Drug Resistance
- Horses/genetics
- Medetomidine/administration & dosage
- Receptors, Adrenergic, alpha-2/genetics
- Sequence Analysis, DNA