Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways

Talat Waseem, Mark Duxbury, Hiromichi Ito, Stanley W Ashley, Malcolm K Robinson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Ghrelin, an orexigenic 28-amino-acid peptide, has been studied primarily in relation to the control of appetite and fat metabolism. In addition to these well-known functions, ghrelin, and its target receptors, growth hormone secretagogue receptors (GHS-Rs), have been localized to neutrophils, lymphocytes, and macrophages, which suggests that ghrelin may be involved in immune modulation.
Original languageEnglish
Pages (from-to)334-42
Number of pages9
JournalSurgery
Volume143
Issue number3
DOIs
Publication statusPublished - 2008

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