Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways

Talat Waseem; Mark Duxbury; Hiromichi Ito; Stanley W Ashley; Malcolm K Robinson

doi:10.1016/j.surg.2007.09.039

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways

Talat Waseem, Mark Duxbury, Hiromichi Ito, Stanley W Ashley, Malcolm K Robinson

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

Ghrelin, an orexigenic 28-amino-acid peptide, has been studied primarily in relation to the control of appetite and fat metabolism. In addition to these well-known functions, ghrelin, and its target receptors, growth hormone secretagogue receptors (GHS-Rs), have been localized to neutrophils, lymphocytes, and macrophages, which suggests that ghrelin may be involved in immune modulation.

Original language	English
Pages (from-to)	334-42
Number of pages	9
Journal	Surgery
Volume	143
Issue number	3
DOIs	https://doi.org/10.1016/j.surg.2007.09.039
Publication status	Published - 2008

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10.1016/j.surg.2007.09.039

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathwaysAccepted author manuscript, 673 KB

http://www.surgjournal.com/article/S0039-6060%2807%2900630-7/abstract

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title = "Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways",

abstract = "Ghrelin, an orexigenic 28-amino-acid peptide, has been studied primarily in relation to the control of appetite and fat metabolism. In addition to these well-known functions, ghrelin, and its target receptors, growth hormone secretagogue receptors (GHS-Rs), have been localized to neutrophils, lymphocytes, and macrophages, which suggests that ghrelin may be involved in immune modulation.",

author = "Talat Waseem and Mark Duxbury and Hiromichi Ito and Ashley, \{Stanley W\} and Robinson, \{Malcolm K\}",

year = "2008",

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AU - Waseem, Talat

AU - Duxbury, Mark

AU - Ito, Hiromichi

AU - Ashley, Stanley W

AU - Robinson, Malcolm K

PY - 2008

Y1 - 2008

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AB - Ghrelin, an orexigenic 28-amino-acid peptide, has been studied primarily in relation to the control of appetite and fat metabolism. In addition to these well-known functions, ghrelin, and its target receptors, growth hormone secretagogue receptors (GHS-Rs), have been localized to neutrophils, lymphocytes, and macrophages, which suggests that ghrelin may be involved in immune modulation.

U2 - 10.1016/j.surg.2007.09.039

DO - 10.1016/j.surg.2007.09.039

M3 - Article

C2 - 18291254

SN - 1532-7361

VL - 143

SP - 334

EP - 342

JO - Surgery

JF - Surgery

IS - 3

ER -

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways

Abstract

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