Expanding roles for S-nitrosylation in the regulation of plant immunity

Sam Borrowman, Jagadis Gupta Kapuganti, Gary J. Loake

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Following pathogen recognition, plant cells produce a nitrosative burst resulting in a striking increase in nitric oxide (NO), altering the redox state of the cell, which subsequently helps orchestrate a plethora of immune responses. NO is a potent redox cue, efficiently relayed between proteins through its co-valent attachment to highly specific, powerfully reactive protein cysteine (Cys) thiols, resulting in formation of protein S-nitrosothiols (SNOs). This process, known as S-nitrosylation, can modulate the function of target proteins, enabling responsiveness to cellular redox changes. Key targets of S-nitrosylation control the production of reactive oxygen species (ROS), the transcription of immune-response genes, the triggering of the hypersensitive response (HR) and the establishment of systemic acquired resistance (SAR). Here, we bring together recent advances in the control of plant immunity by S-nitrosylation, furthering our appreciation of how changes in cellular redox status reprogramme plant immune function.
Original languageEnglish
Pages (from-to)357-368
Number of pages12
JournalFree Radical Biology and Medicine
Volume194
Early online date10 Dec 2022
DOIs
Publication statusPublished - 1 Jan 2023

Keywords / Materials (for Non-textual outputs)

  • S-nitrosylation
  • denitrosylation
  • nitric oxide
  • plant immunity
  • plant defence
  • redox regulation
  • reactive nitrogen species

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