Expanding the Genetic Code of an Animal

Sebastian Greiss; Jason W. Chin

doi:10.1021/ja2054034

Expanding the Genetic Code of an Animal

Sebastian Greiss, Jason W. Chin^*

^*Corresponding author for this work

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

Original language	English
Pages (from-to)	14196-14199
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	36
DOIs	https://doi.org/10.1021/ja2054034
Publication status	Published - 14 Sept 2011

Keywords / Materials (for Non-textual outputs)

UNNATURAL AMINO-ACIDS
SITE-SPECIFIC INCORPORATION
NEMATODE CAENORHABDITIS-ELEGANS
EMBRYONIC CELL LINEAGES
TRANSFER-RNA SYNTHETASE
PHOTO-CROSS-LINKING
ESCHERICHIA-COLI
MAMMALIAN-CELLS
IN-VIVO
RECOMBINANT PROTEINS

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10.1021/ja2054034

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title = "Expanding the Genetic Code of an Animal",

abstract = "Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.",

keywords = "UNNATURAL AMINO-ACIDS, SITE-SPECIFIC INCORPORATION, NEMATODE CAENORHABDITIS-ELEGANS, EMBRYONIC CELL LINEAGES, TRANSFER-RNA SYNTHETASE, PHOTO-CROSS-LINKING, ESCHERICHIA-COLI, MAMMALIAN-CELLS, IN-VIVO, RECOMBINANT PROTEINS",

author = "Sebastian Greiss and Chin, {Jason W.}",

year = "2011",

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doi = "10.1021/ja2054034",

language = "English",

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journal = "Journal of the American Chemical Society",

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T1 - Expanding the Genetic Code of an Animal

AU - Greiss, Sebastian

AU - Chin, Jason W.

PY - 2011/9/14

Y1 - 2011/9/14

N2 - Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

AB - Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

KW - UNNATURAL AMINO-ACIDS

KW - SITE-SPECIFIC INCORPORATION

KW - NEMATODE CAENORHABDITIS-ELEGANS

KW - EMBRYONIC CELL LINEAGES

KW - TRANSFER-RNA SYNTHETASE

KW - PHOTO-CROSS-LINKING

KW - ESCHERICHIA-COLI

KW - MAMMALIAN-CELLS

KW - IN-VIVO

KW - RECOMBINANT PROTEINS

U2 - 10.1021/ja2054034

DO - 10.1021/ja2054034

M3 - Article

SN - 0002-7863

VL - 133

SP - 14196

EP - 14199

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 36

ER -

Expanding the Genetic Code of an Animal

Abstract

Keywords / Materials (for Non-textual outputs)

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