Expanding the Genetic Code of an Animal

Sebastian Greiss, Jason W. Chin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

Original languageEnglish
Pages (from-to)14196-14199
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number36
DOIs
Publication statusPublished - 14 Sept 2011

Keywords / Materials (for Non-textual outputs)

  • UNNATURAL AMINO-ACIDS
  • SITE-SPECIFIC INCORPORATION
  • NEMATODE CAENORHABDITIS-ELEGANS
  • EMBRYONIC CELL LINEAGES
  • TRANSFER-RNA SYNTHETASE
  • PHOTO-CROSS-LINKING
  • ESCHERICHIA-COLI
  • MAMMALIAN-CELLS
  • IN-VIVO
  • RECOMBINANT PROTEINS

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