Expanding the genetic code of Drosophila melanogaster

Ambra Bianco*, Fiona M. Townsley, Sebastian Greiss, Kathrin Lang, Jason W. Chin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic code expansion for unnatural amino acid mutagenesis has, until recently, been limited to cell culture. We demonstrate the site-specific incorporation of unnatural amino acids into proteins in Drosophila melanogaster at different developmental stages, in specific tissues and in a subset of cells within a tissue. This approach provides a foundation for probing and controlling processes in this established metazoan model organism with a new level of molecular precision.

Original languageEnglish
Pages (from-to)748-750
Number of pages3
JournalNature Chemical Biology
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • MAMMALIAN-CELLS
  • RECOMBINANT PROTEINS
  • AMINO-ACIDS
  • TRANSFORMATION
  • EXPRESSION

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