Expanding the phenotypic associations of globular glial tau subtypes

James R. Burrell, Shelley Forrest, Thomas Bak, John R. Hodges, Glenda M. Halliday, Jillian J Kril

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Clinicopathological correlation in non-Alzheimer’s tauopathies is variable, despite refinement of pathological diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathological correlation.
METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging detailed were collected, and cases subtyped according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.
RESULTS: In total, 11 patients (7 males, 4 females, mean age 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioural variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathological correlation.
DISCUSSION: Sub-classification of GGT pathology may be difficult and did not improve clinicopathological correlation. Better biomarkers of tau pathology are needed.
Original languageEnglish
Pages (from-to)6–13
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume4
Early online date8 Apr 2016
DOIs
Publication statusE-pub ahead of print - 8 Apr 2016

Keywords

  • frontotemporal dementia
  • globular glial tau
  • tauopathy
  • clinicopathological correlation

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