Expanding the phenotypic associations of globular glial tau subtypes

James R. Burrell; Shelley Forrest; Thomas Bak; John R. Hodges; Glenda M. Halliday; Jillian J Kril

doi:10.1016/j.dadm.2016.03.006

Expanding the phenotypic associations of globular glial tau subtypes

James R. Burrell, Shelley Forrest, Thomas Bak, John R. Hodges, Glenda M. Halliday, Jillian J Kril

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Clinicopathological correlation in non-Alzheimer’s tauopathies is variable, despite refinement of pathological diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathological correlation.
METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging detailed were collected, and cases subtyped according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.
RESULTS: In total, 11 patients (7 males, 4 females, mean age 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioural variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathological correlation.
DISCUSSION: Sub-classification of GGT pathology may be difficult and did not improve clinicopathological correlation. Better biomarkers of tau pathology are needed.

Original language	English
Pages (from-to)	6–13
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	4
Early online date	8 Apr 2016
DOIs	https://doi.org/10.1016/j.dadm.2016.03.006
Publication status	E-pub ahead of print - 8 Apr 2016

Keywords / Materials (for Non-textual outputs)

frontotemporal dementia
globular glial tau
tauopathy
clinicopathological correlation

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10.1016/j.dadm.2016.03.006

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@article{097093956c1e4b9a8123e8c2ade2cf68,

title = "Expanding the phenotypic associations of globular glial tau subtypes",

abstract = "INTRODUCTION: Clinicopathological correlation in non-Alzheimer{\textquoteright}s tauopathies is variable, despite refinement of pathological diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathological correlation. METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging detailed were collected, and cases subtyped according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.RESULTS: In total, 11 patients (7 males, 4 females, mean age 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioural variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathological correlation. DISCUSSION: Sub-classification of GGT pathology may be difficult and did not improve clinicopathological correlation. Better biomarkers of tau pathology are needed.",

keywords = "frontotemporal dementia, globular glial tau, tauopathy, clinicopathological correlation",

author = "Burrell, {James R.} and Shelley Forrest and Thomas Bak and Hodges, {John R.} and Halliday, {Glenda M.} and Kril, {Jillian J}",

year = "2016",

month = apr,

day = "8",

doi = "10.1016/j.dadm.2016.03.006",

language = "English",

volume = "4",

pages = "6–13",

journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier",

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TY - JOUR

T1 - Expanding the phenotypic associations of globular glial tau subtypes

AU - Burrell, James R.

AU - Forrest, Shelley

AU - Bak, Thomas

AU - Hodges, John R.

AU - Halliday, Glenda M.

AU - Kril, Jillian J

PY - 2016/4/8

Y1 - 2016/4/8

N2 - INTRODUCTION: Clinicopathological correlation in non-Alzheimer’s tauopathies is variable, despite refinement of pathological diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathological correlation. METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging detailed were collected, and cases subtyped according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.RESULTS: In total, 11 patients (7 males, 4 females, mean age 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioural variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathological correlation. DISCUSSION: Sub-classification of GGT pathology may be difficult and did not improve clinicopathological correlation. Better biomarkers of tau pathology are needed.

AB - INTRODUCTION: Clinicopathological correlation in non-Alzheimer’s tauopathies is variable, despite refinement of pathological diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathological correlation. METHODS: Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging detailed were collected, and cases subtyped according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.RESULTS: In total, 11 patients (7 males, 4 females, mean age 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioural variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathological correlation. DISCUSSION: Sub-classification of GGT pathology may be difficult and did not improve clinicopathological correlation. Better biomarkers of tau pathology are needed.

KW - frontotemporal dementia

KW - globular glial tau

KW - tauopathy

KW - clinicopathological correlation

U2 - 10.1016/j.dadm.2016.03.006

DO - 10.1016/j.dadm.2016.03.006

M3 - Article

SN - 2352-8729

VL - 4

SP - 6

EP - 13

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

ER -

Expanding the phenotypic associations of globular glial tau subtypes

Abstract

Keywords / Materials (for Non-textual outputs)

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