Expansion of the metazoan virosphere: progress, pitfalls, and prospects

Research output: Contribution to journalReview articlepeer-review

Abstract

Metagenomic sequencing has led to a recent and rapid expansion of the animal virome. It has uncovered a multitude of new virus lineages from under-sampled host groups, including many that break up long branches in the virus tree, and many that display unexpected genome sizes and structures. Although there are challenges to inferring the existence of a virus from a `virus-like sequence', in the absence of an isolate the analysis of nucleic acid (including small RNAs) and sequence data can provide considerable confidence. As a consequence, this period of molecular natural history is helping to reshape our views of deep virus evolution.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalCurrent Opinion in Virology
Volume31
Early online date17 Aug 2018
DOIs
Publication statusPublished - 31 Aug 2018

Keywords

  • Virus
  • Metagenomics
  • RNAi
  • Host-range
  • Picornavirales

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