Experimental Characterization of Protein Complex Structure, Dynamics, and Assembly

Jonathan N Wells, Joseph A Marsh

Research output: Chapter in Book/Report/Conference proceedingChapter


Experimental methods for the characterization of protein complexes have been instrumental in achieving our current understanding of the protein universe and continue to progress with each year that passes. In this chapter, we review some of the most important tools and techniques in the field, covering the important points in X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, and mass spectrometry. Novel developments are making it possible to study large protein complexes at near-atomic resolutions, and we also now have the ability to study the dynamics and assembly pathways of protein complexes across a range of sizes.

Original languageEnglish
Title of host publicationProtein Complex Assembly
Number of pages25
Publication statusPublished - 2018

Publication series

Name Methods in Molecular Biology


  • Journal Article


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