Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays

Mònica Arman; J Alexandra Rowe

doi:10.1186/1475-2875-7-243

Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays

Mònica Arman, J Alexandra Rowe

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes (IE) is a parasite adhesion phenotype that has been associated with severe malaria in some, but not all, field isolate studies. A variety of experimental conditions have been used to study clumping in vitro, with substantial differences in parasitaemia (Pt), haematocrit (Ht), and time of reaction between studies. It is unknown whether these experimental variables affect the outcome of parasite clumping assays.

Original language	English
Article number	243
Number of pages	15
Journal	Malaria Journal
Volume	7
DOIs	https://doi.org/10.1186/1475-2875-7-243
Publication status	Published - Nov 2008

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abstract = "Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes (IE) is a parasite adhesion phenotype that has been associated with severe malaria in some, but not all, field isolate studies. A variety of experimental conditions have been used to study clumping in vitro, with substantial differences in parasitaemia (Pt), haematocrit (Ht), and time of reaction between studies. It is unknown whether these experimental variables affect the outcome of parasite clumping assays.",

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Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays

Abstract

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Investigation into the potential for a PfEMP1 vaccine to inhibit rosetting and prevent severe malaria.

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Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays

Abstract

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Investigation into the potential for a PfEMP1 vaccine to inhibit rosetting and prevent severe malaria.

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