Exploitation of host cells by Burkholderia pseudomallei

M P Stevens, E E Galyov

Research output: Contribution to journalArticlepeer-review

Abstract

Intracellular bacterial pathogens have evolved mechanisms to enter and exit eukaryotic cells using the power of actin polymerisation and to subvert the activity of cellular enzymes and signal transduction pathways. The proteins deployed by bacteria to subvert cellular processes often mimic eukaryotic proteins in their structure or function. Studies on the exploitation of host cells by the facultative intracellular pathogen Burkholderia pseudomallei are providing novel insights into the pathogenesis of mellioidosis, a serious invasive disease of animals and humans that is endemic in tropical and subtropical areas. B. pseudomallei can invade epithelial cells, survive and proliferate inside phagocytes, escape from endocytic vesicles, form actin-based membrane protrusions and induce host cell fusion. Here we review current understanding of the molecular mechanisms underlying these processes.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalInternational Journal of Medical Microbiology
Volume293
Issue number7-8
Publication statusPublished - Apr 2004

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