Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage

Xiaoujun Liu, Christopher O. C. Bellamy, Linda J. Mullins, Donald Dunbar, John J. Mullins

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

Transgenic animal models are important tools, which have been extensively used to gain insight into the molecular mechanisms of human diseases. We have created two transgenic consomic rat strains, in which malignant hypertension can be induced by administration of a nontoxic xenobiotic. Studies combining quantitative trait locus (QTL) analysis, pathological examination and molecular biological investigation have demonstrated that the renal renin-angiotensin system (RAS), especially angiotensin converting enzyme (Ace), is it key factor affecting the degree of hypertensive kidney damage in these strains.

Original languageEnglish
Title of host publicationLOCAL CARDIAC RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM, SECOND EDITION
EditorsED Frohlich, RN Re
Place of PublicationNEW YORK
PublisherSpringer
Pages51-66
Number of pages16
ISBN (Print)978-1-4419-0527-7
Publication statusPublished - 2009
Event3rd International Workshop on the Local Cardiac Renin Angiotensin Aldosterone System - New Orleans
Duration: 12 Nov 200814 Nov 2008

Conference

Conference3rd International Workshop on the Local Cardiac Renin Angiotensin Aldosterone System
CityNew Orleans
Period12/11/0814/11/08

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