Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Michael Bauer; Tasha Glenn; Eric D Achtyes; Martin Alda; Esen Agaoglu; Kürsat Altınbaş; Ole A Andreassen; Elias Angelopoulos; Raffaella Ardau; Memduha Aydin; Yavuz Ayhan; Christopher Baethge; Rita Bauer; Bernhard T Baune; Ceylan Balaban; Claudia Becerra-Palars; Aniruddh P Behere; Prakash B Behere; Habte Belete; Tilahun Belete; Gabriel Okawa Belizario; Frank Bellivier; Robert H Belmaker; Francesco Benedetti; Michael Berk; Yuly Bersudsky; Şule Bicakci; Harriet Birabwa-Oketcho; Thomas D Bjella; Conan Brady; Jorge Cabrera; Marco Cappucciati; Angela Marianne Paredes Castro; Wei-Ling Chen; Eric Y W Cheung; Silvia Chiesa; Marie Crowe; Alessandro Cuomo; Sara Dallaspezia; Maria Del Zompo; Pratikkumar Desai; Seetal Dodd; Bruno Etain; Andrea Fagiolini; Frederike T Fellendorf; Ewa Ferensztajn-Rochowiak; Jess G Fiedorowicz; Kostas N Fountoulakis; Mark A Frye; Pierre A Geoffroy; Michael J Gitlin; Ana Gonzalez-Pinto; John F Gottlieb; Paul Grof; Bartholomeus C M Haarman; Hirohiko Harima; Mathias Hasse-Sousa; Chantal Henry; Lone Hoffding; Josselin Houenou; Massimiliano Imbesi; Erkki T Isometsä; Maja Ivkovic; Sven Janno; Simon Johnsen; Flávio Kapczinski; Gregory N Karakatsoulis; Mathias Kardell; Lars Vedel Kessing; Seong Jae Kim; Barbara König; Timur L Kot; Michael Koval; Mauricio Kunz; Beny Lafer; Mikael Landén; Erik R Larsen; Melanie Lenger; Rasmus W Licht; Carlos Lopez-Jaramillo; Alan MacKenzie; Helle Østergaard Madsen; Simone Alberte Kongstad A Madsen; Jayant Mahadevan; Agustine Mahardika; Mirko Manchia; Wendy Marsh; Monica Martinez-Cengotitabengoa; Julia Martini; Klaus Martiny; Yuki Mashima; Declan M McLoughlin; Ybe Meesters; Ingrid Melle; Fátima Meza-Urzúa; Pavol Mikolas; Yee Ming Mok; Scott Monteith; Muthukumaran Moorthy; Gunnar Morken; Enrica Mosca; Anton A Mozzhegorov; Rodrigo Munoz; Starlin V Mythri; Fethi Nacef; Ravi K Nadella; Takako Nakanotani; René Ernst Nielsen; Claire O'Donovan; Adel Omrani; Yamima Osher; Uta Ouali; Maja Pantovic-Stefanovic; Pornjira Pariwatcharakul; Joanne Petite; Johannes Petzold; Andrea Pfennig; Yolanda Pica Ruiz; Marco Pinna; Maurizio Pompili; Richard J Porter; Danilo Quiroz; Francisco Diego Rabelo-da-Ponte; Raj Ramesar; Natalie Rasgon; Woraphat Ratta-Apha; Michaela Ratzenhofer; Maria Redahan; M S Reddy; Andreas Reif; Eva Z Reininghaus; Jenny Gringer Richards; Philipp Ritter; Janusz K Rybakowski; Leela Sathyaputri; Angela M Scippa; Christian Simhandl; Daniel Smith; José Smith; Paul W Stackhouse; Dan J Stein; Kellen Stilwell; Sergio Strejilevich; Kuan-Pin Su; Mythily Subramaniam; Ahmad Hatim Sulaiman; Kirsi Suominen; Andi J Tanra; Yoshitaka Tatebayashi; Wen Lin Teh; Leonardo Tondo; Carla Torrent; Daniel Tuinstra; Takahito Uchida; Arne E Vaaler; Eduard Vieta; Biju Viswanath; Maria Yoldi-Negrete; Oguz Kaan Yalcinkaya; Allan H Young; Yosra Zgueb; Peter C Whybrow

doi:10.1186/s40345-023-00303-w

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Michael Bauer^*, Tasha Glenn, Eric D Achtyes, Martin Alda, Esen Agaoglu, Kürsat Altınbaş, Ole A Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P Behere, Prakash B Behere, Habte Belete, Tilahun BeleteGabriel Okawa Belizario, Frank Bellivier, Robert H Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Şule Bicakci, Harriet Birabwa-Oketcho, Thomas D Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y W Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G Fiedorowicz, Kostas N Fountoulakis, Mark A Frye, Pierre A Geoffroy, Michael J Gitlin, Ana Gonzalez-Pinto, John F Gottlieb, Paul Grof, Bartholomeus C M Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T Isometsä, Maja Ivkovic, Sven Janno, Simon Johnsen, Flávio Kapczinski, Gregory N Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara König, Timur L Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landén, Erik R Larsen, Melanie Lenger, Rasmus W Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Østergaard Madsen, Simone Alberte Kongstad A Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M McLoughlin, Ybe Meesters, Ingrid Melle, Fátima Meza-Urzúa, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A Mozzhegorov, Rodrigo Munoz, Starlin V Mythri, Fethi Nacef, Ravi K Nadella, Takako Nakanotani, René Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard J Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-Apha, Michaela Ratzenhofer, Maria Redahan, M S Reddy, Andreas Reif, Eva Z Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K Rybakowski, Leela Sathyaputri, Angela M Scippa, Christian Simhandl, Daniel Smith, José Smith, Paul W Stackhouse, Dan J Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H Young, Yosra Zgueb, Peter C Whybrow

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.

METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.

RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.

CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

Original language	English
Article number	22
Journal	International Journal of Bipolar Disorders
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s40345-023-00303-w
Publication status	Published - 22 Jun 2023

Access to Document

10.1186/s40345-023-00303-w

s40345-023-00303-wFinal published version, 845 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

Bauer, M., Glenn, T., Achtyes, E. D., Alda, M., Agaoglu, E., Altınbaş, K., Andreassen, O. A., Angelopoulos, E., Ardau, R., Aydin, M., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., Balaban, C., Becerra-Palars, C., Behere, A. P., Behere, P. B., Belete, H., ... Whybrow, P. C. (2023). Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder. International Journal of Bipolar Disorders, 11(1), Article 22. https://doi.org/10.1186/s40345-023-00303-w

@article{f28777a526114a61959cb8fc251967fc,

title = "Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder",

abstract = "BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.",

author = "Michael Bauer and Tasha Glenn and Achtyes, {Eric D} and Martin Alda and Esen Agaoglu and K{\"u}rsat Altınba{\c s} and Andreassen, {Ole A} and Elias Angelopoulos and Raffaella Ardau and Memduha Aydin and Yavuz Ayhan and Christopher Baethge and Rita Bauer and Baune, {Bernhard T} and Ceylan Balaban and Claudia Becerra-Palars and Behere, {Aniruddh P} and Behere, {Prakash B} and Habte Belete and Tilahun Belete and Belizario, {Gabriel Okawa} and Frank Bellivier and Belmaker, {Robert H} and Francesco Benedetti and Michael Berk and Yuly Bersudsky and {\c S}ule Bicakci and Harriet Birabwa-Oketcho and Bjella, {Thomas D} and Conan Brady and Jorge Cabrera and Marco Cappucciati and Castro, {Angela Marianne Paredes} and Wei-Ling Chen and Cheung, {Eric Y W} and Silvia Chiesa and Marie Crowe and Alessandro Cuomo and Sara Dallaspezia and {Del Zompo}, Maria and Pratikkumar Desai and Seetal Dodd and Bruno Etain and Andrea Fagiolini and Fellendorf, {Frederike T} and Ewa Ferensztajn-Rochowiak and Fiedorowicz, {Jess G} and Fountoulakis, {Kostas N} and Frye, {Mark A} and Geoffroy, {Pierre A} and Gitlin, {Michael J} and Ana Gonzalez-Pinto and Gottlieb, {John F} and Paul Grof and Haarman, {Bartholomeus C M} and Hirohiko Harima and Mathias Hasse-Sousa and Chantal Henry and Lone Hoffding and Josselin Houenou and Massimiliano Imbesi and Isomets{\"a}, {Erkki T} and Maja Ivkovic and Sven Janno and Simon Johnsen and Fl{\'a}vio Kapczinski and Karakatsoulis, {Gregory N} and Mathias Kardell and Kessing, {Lars Vedel} and Kim, {Seong Jae} and Barbara K{\"o}nig and Kot, {Timur L} and Michael Koval and Mauricio Kunz and Beny Lafer and Mikael Land{\'e}n and Larsen, {Erik R} and Melanie Lenger and Licht, {Rasmus W} and Carlos Lopez-Jaramillo and Alan MacKenzie and Madsen, {Helle {\O}stergaard} and Madsen, {Simone Alberte Kongstad A} and Jayant Mahadevan and Agustine Mahardika and Mirko Manchia and Wendy Marsh and Monica Martinez-Cengotitabengoa and Julia Martini and Klaus Martiny and Yuki Mashima and McLoughlin, {Declan M} and Ybe Meesters and Ingrid Melle and F{\'a}tima Meza-Urz{\'u}a and Pavol Mikolas and Mok, {Yee Ming} and Scott Monteith and Muthukumaran Moorthy and Gunnar Morken and Enrica Mosca and Mozzhegorov, {Anton A} and Rodrigo Munoz and Mythri, {Starlin V} and Fethi Nacef and Nadella, {Ravi K} and Takako Nakanotani and Nielsen, {Ren{\'e} Ernst} and Claire O'Donovan and Adel Omrani and Yamima Osher and Uta Ouali and Maja Pantovic-Stefanovic and Pornjira Pariwatcharakul and Joanne Petite and Johannes Petzold and Andrea Pfennig and Ruiz, {Yolanda Pica} and Marco Pinna and Maurizio Pompili and Porter, {Richard J} and Danilo Quiroz and Rabelo-da-Ponte, {Francisco Diego} and Raj Ramesar and Natalie Rasgon and Woraphat Ratta-Apha and Michaela Ratzenhofer and Maria Redahan and Reddy, {M S} and Andreas Reif and Reininghaus, {Eva Z} and Richards, {Jenny Gringer} and Philipp Ritter and Rybakowski, {Janusz K} and Leela Sathyaputri and Scippa, {Angela M} and Christian Simhandl and Daniel Smith and Jos{\'e} Smith and Stackhouse, {Paul W} and Stein, {Dan J} and Kellen Stilwell and Sergio Strejilevich and Kuan-Pin Su and Mythily Subramaniam and Sulaiman, {Ahmad Hatim} and Kirsi Suominen and Tanra, {Andi J} and Yoshitaka Tatebayashi and Teh, {Wen Lin} and Leonardo Tondo and Carla Torrent and Daniel Tuinstra and Takahito Uchida and Vaaler, {Arne E} and Eduard Vieta and Biju Viswanath and Maria Yoldi-Negrete and Yalcinkaya, {Oguz Kaan} and Young, {Allan H} and Yosra Zgueb and Whybrow, {Peter C}",

note = "Funding Information: Open Access funding enabled and organized by Projekt DEAL. Ole A. Andreassen is supportet by the Research Council of Norway (#223273) and the South Eastern Norway Health Region (#2019–108). Michael Berk is supported by a NHMRC Senior Principal Research Fellowship (1156072). Pierre A. Geoffroy, Chantal Henry and Josselin Houenou received grants from the French Agence Nationale pour la Recherche (ANR-11-IDEX-0004 Labex BioPsy “Olfaction and Bipolar Disorder” collaborative project, ANR-10-COHO-10–01 psyCOH and ANR-DFG ANR-14-CE35–0035 FUNDO). Seong Jae Kim is supported by research funds from the Institute of Medical Science, Chosun University, Republic of Korea, 2022. Mok Yee Ming, Mythily Subramaniam, and Wen Lin Teh received funding from the National Medical Research Centre (NMRC) Centre Grant (Ref No: NMRC/CG/M002/ 2017_IMH). Raj Ramesar is supported by the South African Department of Science and Innovation and Medical Research Council. Eduard Vieta acknowledges the support by CIBER -Consorcio Centro de Investigaci{\'o}n Biom{\'e}dica en Red- (CB07/09/0004), Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation. EV thanks the support of the Spanish Ministry of Science and Innovation (PI18/00805, PI21/00787) integrated into the Plan Nacional de I + D + I and co-financed by the ISCIII-Subdirecci{\'o}n General de Evaluaci{\'o}n and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Thanks the support of the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151). Biju Viswanath is supported by the Intermediate (Clinical and Public Health) Fellowship (IA/CPHI/20/1/505266) of the DBT/ Wellcome Trust India Alliance. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = jun,

day = "22",

doi = "10.1186/s40345-023-00303-w",

language = "English",

volume = "11",

journal = "International Journal of Bipolar Disorders",

issn = "2194-7511",

publisher = "Springer",

number = "1",

}

Bauer, M, Glenn, T, Achtyes, ED, Alda, M, Agaoglu, E, Altınbaş, K, Andreassen, OA, Angelopoulos, E, Ardau, R, Aydin, M, Ayhan, Y, Baethge, C, Bauer, R, Baune, BT, Balaban, C, Becerra-Palars, C, Behere, AP, Behere, PB, Belete, H, Belete, T, Belizario, GO, Bellivier, F, Belmaker, RH, Benedetti, F, Berk, M, Bersudsky, Y, Bicakci, Ş, Birabwa-Oketcho, H, Bjella, TD, Brady, C, Cabrera, J, Cappucciati, M, Castro, AMP, Chen, W-L, Cheung, EYW, Chiesa, S, Crowe, M, Cuomo, A, Dallaspezia, S, Del Zompo, M, Desai, P, Dodd, S, Etain, B, Fagiolini, A, Fellendorf, FT, Ferensztajn-Rochowiak, E, Fiedorowicz, JG, Fountoulakis, KN, Frye, MA, Geoffroy, PA, Gitlin, MJ, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Haarman, BCM, Harima, H, Hasse-Sousa, M, Henry, C, Hoffding, L, Houenou, J, Imbesi, M, Isometsä, ET, Ivkovic, M, Janno, S, Johnsen, S, Kapczinski, F, Karakatsoulis, GN, Kardell, M, Kessing, LV, Kim, SJ, König, B, Kot, TL, Koval, M, Kunz, M, Lafer, B, Landén, M, Larsen, ER, Lenger, M, Licht, RW, Lopez-Jaramillo, C, MacKenzie, A, Madsen, HØ, Madsen, SAKA, Mahadevan, J, Mahardika, A, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Martini, J, Martiny, K, Mashima, Y, McLoughlin, DM, Meesters, Y, Melle, I, Meza-Urzúa, F, Mikolas, P, Mok, YM, Monteith, S, Moorthy, M, Morken, G, Mosca, E, Mozzhegorov, AA, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nakanotani, T, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Ouali, U, Pantovic-Stefanovic, M, Pariwatcharakul, P, Petite, J, Petzold, J, Pfennig, A, Ruiz, YP, Pinna, M, Pompili, M, Porter, RJ, Quiroz, D, Rabelo-da-Ponte, FD, Ramesar, R, Rasgon, N, Ratta-Apha, W, Ratzenhofer, M, Redahan, M, Reddy, MS, Reif, A, Reininghaus, EZ, Richards, JG, Ritter, P, Rybakowski, JK, Sathyaputri, L, Scippa, AM, Simhandl, C, Smith, D, Smith, J, Stackhouse, PW, Stein, DJ, Stilwell, K, Strejilevich, S, Su, K-P, Subramaniam, M, Sulaiman, AH, Suominen, K, Tanra, AJ, Tatebayashi, Y, Teh, WL, Tondo, L, Torrent, C, Tuinstra, D, Uchida, T, Vaaler, AE, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Yalcinkaya, OK, Young, AH, Zgueb, Y & Whybrow, PC 2023, 'Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder', International Journal of Bipolar Disorders, vol. 11, no. 1, 22. https://doi.org/10.1186/s40345-023-00303-w

TY - JOUR

T1 - Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

AU - Bauer, Michael

AU - Glenn, Tasha

AU - Achtyes, Eric D

AU - Alda, Martin

AU - Agaoglu, Esen

AU - Altınbaş, Kürsat

AU - Andreassen, Ole A

AU - Angelopoulos, Elias

AU - Ardau, Raffaella

AU - Aydin, Memduha

AU - Ayhan, Yavuz

AU - Baethge, Christopher

AU - Bauer, Rita

AU - Baune, Bernhard T

AU - Balaban, Ceylan

AU - Becerra-Palars, Claudia

AU - Behere, Aniruddh P

AU - Behere, Prakash B

AU - Belete, Habte

AU - Belete, Tilahun

AU - Belizario, Gabriel Okawa

AU - Bellivier, Frank

AU - Belmaker, Robert H

AU - Benedetti, Francesco

AU - Berk, Michael

AU - Bersudsky, Yuly

AU - Bicakci, Şule

AU - Birabwa-Oketcho, Harriet

AU - Bjella, Thomas D

AU - Brady, Conan

AU - Cabrera, Jorge

AU - Cappucciati, Marco

AU - Castro, Angela Marianne Paredes

AU - Chen, Wei-Ling

AU - Cheung, Eric Y W

AU - Chiesa, Silvia

AU - Crowe, Marie

AU - Cuomo, Alessandro

AU - Dallaspezia, Sara

AU - Del Zompo, Maria

AU - Desai, Pratikkumar

AU - Dodd, Seetal

AU - Etain, Bruno

AU - Fagiolini, Andrea

AU - Fellendorf, Frederike T

AU - Ferensztajn-Rochowiak, Ewa

AU - Fiedorowicz, Jess G

AU - Fountoulakis, Kostas N

AU - Frye, Mark A

AU - Geoffroy, Pierre A

AU - Gitlin, Michael J

AU - Gonzalez-Pinto, Ana

AU - Gottlieb, John F

AU - Grof, Paul

AU - Haarman, Bartholomeus C M

AU - Harima, Hirohiko

AU - Hasse-Sousa, Mathias

AU - Henry, Chantal

AU - Hoffding, Lone

AU - Houenou, Josselin

AU - Imbesi, Massimiliano

AU - Isometsä, Erkki T

AU - Ivkovic, Maja

AU - Janno, Sven

AU - Johnsen, Simon

AU - Kapczinski, Flávio

AU - Karakatsoulis, Gregory N

AU - Kardell, Mathias

AU - Kessing, Lars Vedel

AU - Kim, Seong Jae

AU - König, Barbara

AU - Kot, Timur L

AU - Koval, Michael

AU - Kunz, Mauricio

AU - Lafer, Beny

AU - Landén, Mikael

AU - Larsen, Erik R

AU - Lenger, Melanie

AU - Licht, Rasmus W

AU - Lopez-Jaramillo, Carlos

AU - MacKenzie, Alan

AU - Madsen, Helle Østergaard

AU - Madsen, Simone Alberte Kongstad A

AU - Mahadevan, Jayant

AU - Mahardika, Agustine

AU - Manchia, Mirko

AU - Marsh, Wendy

AU - Martinez-Cengotitabengoa, Monica

AU - Martini, Julia

AU - Martiny, Klaus

AU - Mashima, Yuki

AU - McLoughlin, Declan M

AU - Meesters, Ybe

AU - Melle, Ingrid

AU - Meza-Urzúa, Fátima

AU - Mikolas, Pavol

AU - Mok, Yee Ming

AU - Monteith, Scott

AU - Moorthy, Muthukumaran

AU - Morken, Gunnar

AU - Mosca, Enrica

AU - Mozzhegorov, Anton A

AU - Munoz, Rodrigo

AU - Mythri, Starlin V

AU - Nacef, Fethi

AU - Nadella, Ravi K

AU - Nakanotani, Takako

AU - Nielsen, René Ernst

AU - O'Donovan, Claire

AU - Omrani, Adel

AU - Osher, Yamima

AU - Ouali, Uta

AU - Pantovic-Stefanovic, Maja

AU - Pariwatcharakul, Pornjira

AU - Petite, Joanne

AU - Petzold, Johannes

AU - Pfennig, Andrea

AU - Ruiz, Yolanda Pica

AU - Pinna, Marco

AU - Pompili, Maurizio

AU - Porter, Richard J

AU - Quiroz, Danilo

AU - Rabelo-da-Ponte, Francisco Diego

AU - Ramesar, Raj

AU - Rasgon, Natalie

AU - Ratta-Apha, Woraphat

AU - Ratzenhofer, Michaela

AU - Redahan, Maria

AU - Reddy, M S

AU - Reif, Andreas

AU - Reininghaus, Eva Z

AU - Richards, Jenny Gringer

AU - Ritter, Philipp

AU - Rybakowski, Janusz K

AU - Sathyaputri, Leela

AU - Scippa, Angela M

AU - Simhandl, Christian

AU - Smith, Daniel

AU - Smith, José

AU - Stackhouse, Paul W

AU - Stein, Dan J

AU - Stilwell, Kellen

AU - Strejilevich, Sergio

AU - Su, Kuan-Pin

AU - Subramaniam, Mythily

AU - Sulaiman, Ahmad Hatim

AU - Suominen, Kirsi

AU - Tanra, Andi J

AU - Tatebayashi, Yoshitaka

AU - Teh, Wen Lin

AU - Tondo, Leonardo

AU - Torrent, Carla

AU - Tuinstra, Daniel

AU - Uchida, Takahito

AU - Vaaler, Arne E

AU - Vieta, Eduard

AU - Viswanath, Biju

AU - Yoldi-Negrete, Maria

AU - Yalcinkaya, Oguz Kaan

AU - Young, Allan H

AU - Zgueb, Yosra

AU - Whybrow, Peter C

N1 - Funding Information: Open Access funding enabled and organized by Projekt DEAL. Ole A. Andreassen is supportet by the Research Council of Norway (#223273) and the South Eastern Norway Health Region (#2019–108). Michael Berk is supported by a NHMRC Senior Principal Research Fellowship (1156072). Pierre A. Geoffroy, Chantal Henry and Josselin Houenou received grants from the French Agence Nationale pour la Recherche (ANR-11-IDEX-0004 Labex BioPsy “Olfaction and Bipolar Disorder” collaborative project, ANR-10-COHO-10–01 psyCOH and ANR-DFG ANR-14-CE35–0035 FUNDO). Seong Jae Kim is supported by research funds from the Institute of Medical Science, Chosun University, Republic of Korea, 2022. Mok Yee Ming, Mythily Subramaniam, and Wen Lin Teh received funding from the National Medical Research Centre (NMRC) Centre Grant (Ref No: NMRC/CG/M002/ 2017_IMH). Raj Ramesar is supported by the South African Department of Science and Innovation and Medical Research Council. Eduard Vieta acknowledges the support by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB07/09/0004), Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation. EV thanks the support of the Spanish Ministry of Science and Innovation (PI18/00805, PI21/00787) integrated into the Plan Nacional de I + D + I and co-financed by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Thanks the support of the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151). Biju Viswanath is supported by the Intermediate (Clinical and Public Health) Fellowship (IA/CPHI/20/1/505266) of the DBT/ Wellcome Trust India Alliance. Publisher Copyright: © 2023, The Author(s).

PY - 2023/6/22

Y1 - 2023/6/22

N2 - BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

AB - BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.

U2 - 10.1186/s40345-023-00303-w

DO - 10.1186/s40345-023-00303-w

M3 - Article

C2 - 37347392

SN - 2194-7511

VL - 11

JO - International Journal of Bipolar Disorders

JF - International Journal of Bipolar Disorders

IS - 1

M1 - 22

ER -

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Abstract / Description of output

Access to Document

Fingerprint

Cite this